This product is a Ramos (RA 1) B cell engineering tool based on the Dendrimers (N-acetyl-D-glucosamine, sialic acid/Wheat germ agglutinin) delivery system and CRISPR-based (AAVS1-crispr RNA-SpCas9-RS-1) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | EGFR |
| Insert Clone | BG-27A |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | crispr RNA |
| Nuclease | SpCas9 |
| Enhancer | RS-1 |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Dendrimers |
| Ligand/Receptor | N-acetyl-D-glucosamine, sialic acid/Wheat germ agglutinin |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | 15-188 |
| Charge (mv) | -31 to -200 |
| Total Atom Count | -64000000 |
| Surface Atoms (%) | -0.5 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | RABV |
| Vector Name | BCpCDH8 |
| Targeting Diseases | Pancreatic cancer; Ovarian cancer; Breast cancer; Colon cancer |
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