This product is a BC-3 B cell engineering tool based on the Gold nanoparticles (EpCAM aptamer/Epithelial cell adhesion molecule) delivery system and CRISPR-based (AAVS1-huIgH296-SpCas9-3'-Azido-3'-deoxythymidine) genome editor.
| Host Cell | BC-3 |
| Target | EGFR |
| Insert Clone | BG-22A |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | huIgH296 |
| Nuclease | SpCas9 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | EpCAM aptamer/Epithelial cell adhesion molecule |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | <2300 |
| Charge (mv) | -2 to -31 |
| Total Atom Count | -64000000 |
| Surface Atoms (%) | -0.5 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Pancreatic cancer; Ovarian cancer; Breast cancer; Colon cancer |
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