This product is a Ramos (RA 1) B cell engineering tool based on the Gold nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (hROSA26-sgRNA-Cpf1-RS-1) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | EphA2 |
| Insert Clone | B6CR73 |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | Regorafenib |
| Particle Size | 10-50 |
| Charge (mv) | 10 to 30 |
| Total Atom Count | -70000000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Colon cancer; Lung cancer; Brain cancer; Renal cancer; Leukemia |
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