This product is a Ramos (RA 1) B cell engineering tool based on the Nanoparticles (N-acetyl-D-glucosamine, sialic acid/Wheat germ agglutinin) delivery system and CRISPR-based (SHS-289-tracr RNA-Cas9-L755507) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | EphA2 |
| Insert Clone | BG-26G |
| Safe Harbor Sites (SHS) | SHS-289 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | L755507 |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Nanoparticles |
| Ligand/Receptor | N-acetyl-D-glucosamine, sialic acid/Wheat germ agglutinin |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | ≤10000 |
| Charge (mv) | -5 to -50 |
| Total Atom Count | -64,000,000 |
| Surface Atoms (%) | -0.5 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | VSV |
| Vector Name | BCpCDH7 |
| Targeting Diseases | Breast cancer; Prostate cancer |
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