This product is a Raji-Luc2 B cell engineering tool based on the Magnetic nanoparticles (MUC1 aptamer/MUC1) delivery system and CRISPR-based (SHS-317-crRNA:tracrRNA duplex-Cas12-Brefeldin A) genome editor.
| Host Cell | Raji-Luc2 |
| Target | EZR |
| Insert Clone | 6F1C3CR |
| Safe Harbor Sites (SHS) | SHS-317 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas12 |
| Enhancer | Brefeldin A |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Large DNA sequences |
| Vehicles | Magnetic nanoparticles |
| Ligand/Receptor | MUC1 aptamer/MUC1 |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | 20-2850 |
| Charge (mv) | 10 to 45 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | Baculovirus-AAV |
| Vector Name | BCpCDH4 |
| Targeting Diseases | Breast cancer; Colon cancer; Lung cancer; Ovarian cancer |
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