This product is a P3HR-1 B cell engineering tool based on the Gold nanoparticles (EGFR mAb/Epidermal Growth Factor Receptor) delivery system and CRISPR-based (CCR5-tracr RNA-SpCas9-Brefeldin A) genome editor.
| Host Cell | P3HR-1 |
| Target | EZR |
| Insert Clone | BCGR-1443CR |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | tracr RNA |
| Nuclease | SpCas9 |
| Enhancer | Brefeldin A |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | EGFR mAb/Epidermal Growth Factor Receptor |
| Active Agents | Bortezomib |
| Particle Size | <500 |
| Charge (mv) | -25 to -125 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | Adenoviruses |
| Vector Name | BCpCDH3 |
| Targeting Diseases | Breast cancer; Colon cancer; Lung cancer; Ovarian cancer |
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