This product is a RPMI 1788 B cell engineering tool based on the Nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (SHS-323-crRNA:tracrRNA duplex-Cas12-SCR7 pyrazine) genome editor.
| Host Cell | RPMI 1788 |
| Target | EZR |
| Insert Clone | B6CR248 |
| Safe Harbor Sites (SHS) | SHS-323 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas12 |
| Enhancer | SCR7 pyrazine |
| Targeting Strategy | Enzyme responsive, time-dependent |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | [Ru(bpy)2(tip)]2+, RBT |
| Particle Size | <100 |
| Charge (mv) | -25 to -47 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Colon cancer; Lung cancer; Ovarian cancer |
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