This product is a RPMI 1788 B cell engineering tool based on the Gold nanoparticles (MUC1 aptamer/MUC1) delivery system and CRISPR-based (hROSA26-crRNA:tracrRNA duplex-Cas12-(Z)-4-Hydroxytamoxifen) genome editor.
| Host Cell | RPMI 1788 |
| Target | EZR |
| Insert Clone | BCGR-1441CR |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas12 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | pH responsive |
| Insertion sites | Mouse genomeD-4(2) |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | MUC1 aptamer/MUC1 |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | <1000 |
| Charge (mv) | 0 to -16 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Breast cancer; Colon cancer; Lung cancer; Ovarian cancer |
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