This product is a DS-1 B cell engineering tool based on the Magnetic nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (CCR5-crRNA:tracrRNA duplex-Cas12-L755507) genome editor.
| Host Cell | DS-1 |
| Target | FAP |
| Insert Clone | B6CR261 |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas12 |
| Enhancer | L755507 |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Large DNA sequences |
| Vehicles | Magnetic nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | 20-2850 |
| Charge (mv) | -1 to -20 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | MMLV |
| Vector Name | BCpCDH5 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Colon cancer |
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