This product is a U266B1 [U266] B cell engineering tool based on the Magnetic nanoparticles (MUC1 aptamer/MUC1) delivery system and CRISPR-based (AAVS1-huIgH296-SpCas9-Brefeldin A) genome editor.
| Host Cell | U266B1 [U266] |
| Target | MIF |
| Insert Clone | RAB2I |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | huIgH296 |
| Nuclease | SpCas9 |
| Enhancer | Brefeldin A |
| Targeting Strategy | pH responsive |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Magnetic nanoparticles |
| Ligand/Receptor | MUC1 aptamer/MUC1 |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | 22-50 |
| Charge (mv) | 11-91 |
| Total Atom Count | -23000000 |
| Surface Atoms (%) | -4 |
| Specific Surface Area (m2/g) | -7 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Lung cancer; Brain cancer; Colon cancer; Ovarian cancer; Liver cancer |
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