This product is a Ramos (RA 1) B cell engineering tool based on the Dendrimers (Folate/ Folate Receptor) delivery system and CRISPR-based (CCR5-huIgH296-NLS-Cas9-RS-1) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | NAB2 |
| Insert Clone | 1E12CR |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | huIgH296 |
| Nuclease | NLS-Cas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Dendrimers |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | Paclitaxel, chlorin e6 |
| Particle Size | ≤900 |
| Charge (mv) | ≤50 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | Adenoviruses |
| Vector Name | BCpCDH3 |
| Targeting Diseases | Lung canccer; Ovarian cancer; Liver cancer |
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