This product is a Jiyoye [Jijoye, P-2003, P-3J] B cell engineering tool based on the Nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (CCR5-crRNA:tracrRNA duplex-Cas12-L755507) genome editor.
| Host Cell | Jiyoye [Jijoye, P-2003, P-3J] |
| Target | NAB2 |
| Insert Clone | 4H6CR |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas12 |
| Enhancer | L755507 |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Large DNA sequences |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | Celastrol |
| Particle Size | 20-150 |
| Charge (mv) | 17 to 58 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Lung canccer; Ovarian cancer; Liver cancer |
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