This product is a SU-DHL-10 B cell engineering tool based on the Nanoparticles (Transferrin/Transferrin receptor) delivery system and CRISPR-based (SHS-289-huIgH296-Cas12-Nocodazole) genome editor.
| Host Cell | SU-DHL-10 |
| Target | NEUROG3 |
| Insert Clone | 3F9CR |
| Safe Harbor Sites (SHS) | SHS-289 |
| gRNA | huIgH296 |
| Nuclease | Cas12 |
| Enhancer | Nocodazole |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Transferrin/Transferrin receptor |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | 20-150 |
| Charge (mv) | -15 to -185 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | Adenoviruses |
| Vector Name | BCpCDH3 |
| Targeting Diseases | Lung cancer; Breast cancer; Prostate cancer; Melanoma |
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