This product is a Ramos (RA 1) B cell engineering tool based on the Microbubbles (AS1411 aptamer/Nucleolin) delivery system and CRISPR-based (AAVS1-crispr RNA-SpCas9-RS-1) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | NEUROG3 |
| Insert Clone | 4E9CR |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | crispr RNA |
| Nuclease | SpCas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | Enzyme responsive, time-dependent |
| Insertion sites | Large DNA sequences |
| Vehicles | Microbubbles |
| Ligand/Receptor | AS1411 aptamer/Nucleolin |
| Active Agents | Thymoquinone |
| Particle Size | 10-50 |
| Charge (mv) | 0 to -16 |
| Total Atom Count | -70000000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Lung cancer; Breast cancer; Prostate cancer; Melanoma |
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