This product is a Ramos (RA 1) B cell engineering tool based on the Dendrimers (SS-Fc/Carcinoembryonic antigen) delivery system and CRISPR-based (hROSA26-tracr RNA-Cas9-(Z)-4-Hydroxytamoxifen) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | NEUROG3 |
| Insert Clone | BCGW-1346CR |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Dendrimers |
| Ligand/Receptor | SS-Fc/Carcinoembryonic antigen |
| Active Agents | Bortezomib |
| Particle Size | ≤900 |
| Charge (mv) | -2 to -30 |
| Total Atom Count | -70000000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | MSCV |
| Vector Name | BCpCDH6 |
| Targeting Diseases | Lung cancer; Breast cancer; Prostate cancer; Melanoma |
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