This product is a GA-10 B cell engineering tool based on the Solid lipid nanoparticles (EGFR mAb/Epidermal GrowthFactor Receptor) delivery system and CRISPR-based (SHS-321-SpCas9-NLS-Cas9-3'-Azido-3'-deoxythymidine) genome editor.
| Host Cell | GA-10 |
| Target | NEUROG3 |
| Insert Clone | 4C11CR |
| Safe Harbor Sites (SHS) | SHS-321 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | Enzyme responsive, time-dependent |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | EGFR mAb/Epidermal Growth Factor Receptor |
| Active Agents | Celastrol |
| Particle Size | 1-100 |
| Charge (mv) | <-1 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | VSV |
| Vector Name | BCpCDH7 |
| Targeting Diseases | Lung cancer; Breast cancer; Prostate cancer; Melanoma |
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