This product is a DG-75 [D.G.-75] B cell engineering tool based on the Gold nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (SHS-323-SpCas9-NLS-Cas9-RS-1) genome editor.
| Host Cell | DG-75 [D.G.-75] |
| Target | NEUROG3 |
| Insert Clone | 3F8CR |
| Safe Harbor Sites (SHS) | SHS-323 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | pH responsive |
| Insertion sites | Human genome |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | <1660 |
| Charge (mv) | <-25 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Lung cancer; Breast cancer; Prostate cancer; Melanoma |
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