This product is a Raji-Luc2 B cell engineering tool based on the Microbubbles (AS1411 aptamer/Nucleolin) delivery system and CRISPR-based (CCR5-crispr RNA-SpCas9-RS-1) genome editor.
| Host Cell | Raji-Luc2 |
| Target | SNCG |
| Insert Clone | 3356ABCR |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | crispr RNA |
| Nuclease | SpCas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Microbubbles |
| Ligand/Receptor | AS1411 aptamer/Nucleolin |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | <1660 |
| Charge (mv) | < 0 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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