This product is a RPMI 8226 B cell engineering tool based on the Solid lipid nanoparticles (EGFR mAb/Epidermal Growth Factor Receptor) delivery system and CRISPR-based (SHS-289-crRNA:tracrRNA duplex-Cas12-Nocodazole) genome editor.
| Host Cell | RPMI 8226 |
| Target | SPINT1 |
| Insert Clone | BCGS-3971CR |
| Safe Harbor Sites (SHS) | SHS-289 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas12 |
| Enhancer | Nocodazole |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Mouse genome E-1 |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | EGFR mAb/Epidermal Growth Factor Receptor |
| Active Agents | DOX |
| Particle Size | 10-50 |
| Charge (mv) | -3 to -71 |
| Total Atom Count | -70000000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Colorectal cancer; Breast cancer; Lung cancer; Liver cancer |
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