This product is a RPMI 8226 B cell engineering tool based on the Gold nanoparticles (AS1411 aptamer/Nucleolin) delivery system and CRISPR-based (hROSA26-crispr RNA-SpCas9-RS-1) genome editor.
| Host Cell | RPMI 8226 |
| Target | SPINT1 |
| Insert Clone | BCGS-5255CR |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | crispr RNA |
| Nuclease | SpCas9 |
| Enhancer | RS-1 |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Large DNA sequences |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | AS1411 aptamer/Nucleolin |
| Active Agents | Thymoquinone |
| Particle Size | 20-2850 |
| Charge (mv) | 3 to 20 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Colorectal cancer; Breast cancer; Lung cancer; Liver cancer |
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