3-N-Maleimidobenzoic Acid-NHS (MBS) Heterobifunctional Crosslinker (CAT#: OLY-1023-YS106)
Datasheet MSDSCas No.: 58626-38-3
PRODUCT INFORMATION
Description
MBS is a non-cleavable, heterobifunctional crosslinker. It features an amine-reactive N-hydroxysuccinimide (NHS) ester and a sulfhydryl-reactive maleimide group. The NHS ester reacts with primary amines (lysines) at pH 7.0-9.0. The maleimide group targets thiols (cysteines) at pH 6.5-7.5. These two groups are separated by a short, rigid aromatic (benzoic acid) spacer. This rigidity provides a defined, short-range linkage. MBS is widely used to conjugate proteins to peptides, and its hydrophobic nature makes it membrane-permeable for intracellular crosslinking.
Molecular Weight
314.25
Purity
>98.0%
Formula
C₁₅H₁₀N₂O₆
Product Type
Heterobifunctional Crosslinkers
Group 1
Maleimide
Group 2
NHS
Form (20 deg.C)
Solid
Storage Condition
Store under inert gas, 2-8°C
Molecular Structure
For Research Use Only | Not For Clinical Use
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