Cas No.: 68528-80-3
PRODUCT INFORMATION
Description
DSS is a classic homobifunctional, amine-reactive crosslinker. It features two N-hydroxysuccinimide (NHS) ester groups separated by an 8-carbon (C8) aliphatic suberate spacer. NHS esters react efficiently with primary amines (lysines) at pH 7.0-9.0 to form stable, non-cleavable amide bonds. DSS is widely used to study protein-protein interactions by covalently "freezing" them. Its medium-length, hydrophobic spacer arm makes it membrane-permeable, allowing for crosslinking of proteins both in vitro and inside living cells. It is the non-cleavable analogue of DSP.
Molecular Weight
368.34
Purity
>98.0%
Formula
C₁₆H₂₀N₂O₈
Product Type
Homobifunctional Crosslinkers
Group 1
NHS
Group 2
NHS
Form (20 deg.C)
Solid
Storage Condition
Store under inert gas, 2-8°C
Molecular Structure
For Research Use Only | Not For Clinical Use
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