Cas No.: 2499715-43-2
PRODUCT INFORMATION
Description
CPO-PFP is a highly specialized crosslinker for the site-specific modification of N-terminal cysteine (N-Cys) residues. It features a highly reactive pentafluorophenyl (PFP) active ester and a cyclopropene (CPO) group. The PFP ester first acylates the alpha-amine of the N-terminus. This tethers the linker, positioning the CPO moiety for a rapid intramolecular reaction with the N-Cys thiol. This proximity-driven mechanism grants exceptional selectivity for N-terminal cysteines over internal cysteine residues, making it invaluable for creating homogenous, site-specific protein conjugates or for peptide stapling.
Molecular Weight
306.19
Purity
>98.0%
Formula
C₁₃H₇F₅O₃
Product Type
Heterobifunctional Crosslinkers ; Selective N-Terminal Cysteine Residue Conjugation Reagents
Group 1
Other
Group 2
Other
Form (20 deg.C)
Solid
Storage Condition
Store under inert gas, -20°C
Molecular Structure
For Research Use Only | Not For Clinical Use
Related products
- Hydrazide-PEG4-desthiobiotin Biotins Conjugation Reagent (CAT#: OLY-1023-YS212)
- Azido-PEG4-amine PEGylation Crosslinker (CAT#: OLY-1023-YS65)
- 3-N-Maleimidobenzoic Acid-NHS (MBS) Heterobifunctional Crosslinker (CAT#: OLY-1023-YS106)
- Methyltetrazine-NHS Ester Copper-Free Click Chemistry Reagent (CAT#: OLY-1023-YS228)
- Palm-Glu(OSu)-OtBu Albumin Binding Conjugation Reagent (CAT#: OLY-1023-YS178)
- Ethyl 6-[(2-Cyanoethoxy)(4,4-diphenylcyclohexyloxy)phosphoryloxy]hexanoate Albumin Binding Conjugation Reagent (CAT#: OLY-1023-YS182)
- N-Hydroxysulfosuccinimide Sodium Salt (Sulfo-NHS) Zero-Length Crosslinker (CAT#: OLY-1023-YS288)
- Mal-amido-PEG4-acid PEGylation Crosslinker (CAT#: OLY-1023-YS79)
Online Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.