Acetylthio-PEG4-alkyne Heterobifunctional Crosslinker (CAT#: OLY-1023-YS35)

Description

This is a heterobifunctional, hydrophilic linker for 'Click Chemistry' and thiol-based conjugations. It contains: 1) A terminal alkyne group for Copper(I)-catalyzed (CuAAC) click reactions with azides. 2) An S-acetyl-protected thiol group. This thioester is stable to click conditions but can be selectively cleaved with a mild base (e.g., hydroxylamine) to reveal a free sulfhydryl group. This free thiol can then be used for a subsequent conjugation, such as reacting with a maleimide or immobilizing onto a gold surface. The 4-unit PEG spacer adds hydrophilicity.

Molecular Weight

290.37

Purity

>98.0%

Formula

C₁₃H₂₂O₅S

Product Type

Heterobifunctional Crosslinkers

Group 1

Alkyne

Group 2

Other

Form (20 deg.C)

Liquid

Storage Condition

Store under inert gas, -20°C

Molecular Structure