Mal-amido-PEG4-acid PEGylation Crosslinker (CAT#: OLY-1023-YS79)

Description

This is a heterobifunctional, hydrophilic PEGylation crosslinker. It features a sulfhydryl-reactive maleimide group and a terminal carboxylic acid, separated by a 4-unit PEG spacer. The maleimide group reacts specifically with thiols (e.g., cysteine residues) at pH 6.5-7.5 to form a stable thioether bond. The carboxylic acid can be activated (e.g., with EDC/NHS) to react with primary amines (e.g., lysine residues). This linker is ideal for conjugating thiol-containing molecules to amine-containing molecules (or vice-versa), with the PEG4 spacer enhancing solubility.

Molecular Weight

416.43

Purity

>95.0%

Formula

C₁₈H₂₈N₂O₉

Product Type

Heterobifunctional Crosslinkers ; PEGylation Reagents

Group 1

Maleimide

Group 2

COOH

Form (20 deg.C)

Solid

Storage Condition

2-8°C

Molecular Structure