Bis-PEG5-NHS Ester PEGylation Crosslinker (CAT#: OLY-1023-YS167)

Description

This is a homobifunctional, amine-reactive, and hydrophilic PEGylation crosslinker. It features two N-hydroxysuccinimide (NHS) ester groups separated by a 5-unit polyethylene glycol (PEG) spacer. NHS esters react efficiently with primary amines (lysines) at pH 7.0-9.0 to form stable amide bonds. Unlike hydrophobic linkers (e.g., DSS), the long, hydrophilic PEG5 spacer arm makes this linker water-soluble. This is ideal for crosslinking proteins in aqueous solution, as it helps prevent aggregation and precipitation of the conjugate.

Molecular Weight

532.50

Formula

C₂₂H₃₂N₂O₁₃

Product Type

Homobifunctional Crosslinkers ; PEGylation Reagents

Group 1

NHS

Group 2

NHS

Form (20 deg.C)

Liquid

Storage Condition

Store under inert gas, <0°C

Molecular Structure