Home > Products > Ad Fiber Knob & CD40 > Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Fab-scFv-Fc)

Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Fab-scFv-Fc)  (CAT#: FABVC-002)

Recombinant Anti-Ad fiber knob x Anti-CD40 Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-Ad fiber knob antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-CD40 to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing.
Datasheet INQUIRY

Specifications

Targets
Ad Fiber Knob & CD40
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Acute myeloid leukaemic (AML)

Targets

Target 1
Ad Fiber Knob
Alternative Names
Ad fiber knob; Adenovirus fiber knob; adenovirus fiber protein; knob domain of Ad fiber
Target 2
CD40
Gene ID
UniProt ID
Alternative Names
CD40; CD40 molecule; p50; Bp50; CDW40; TNFRSF5
Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.
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