Name: Recombinant Human Anti-SIRPα x Anti-CEA Bispecific Antibody (Tandem scFv)
SKU: KN-1025-N27
Rating: 5 (1 reviews)

Recombinant Anti-SIRPα x Anti-CEA Bispecific Antibody (Tandem scFv) is designed to be expressed as a scFv from an anti-SIRPα antibody variable domains fused with a scFv from an anti-CEA antibody variable domains. It contains a His-tag at the C/N terminus for affinity purification. The BsAb exits as monomer in reducing and non-reducing conditions. This BsAb can retarget macrophages to CEA+ tumor cells. It is designed for the research of Colorectal cancer (CRC); Breast cancer; Lung cancer; Gastric cancer therapy.

Datasheet INQUIRY

Specifications

Targets

SIRPα & CEA

Type

Tandem scFv

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Colorectal cancer (CRC); Breast cancer; Lung cancer; Gastric cancer

Host Animal 1

Human

Host Animal 2

Human

Targets

Target 1

SIRPα

Gene ID

140885

UniProt ID

P78324

Alternative Names

SHPS-1; CD172A; p84; MYD-1; BIT; PTPNS1; SIRPA; signal regulatory protein alpha; MFR; P84; MYD1; SIRP; SHPS1; Tyrosine-protein phosphatase non-receptor type substrate 1; SHP substrate 1; Brain Ig-like molecule with tyrosine-based activation motifs; CD172 antigen-like family member A; Inhibitory receptor SHPS-1; Macrophage fusion receptor; MyD-1 antigen; Signal-regulatory protein alpha-1; Sirp-alpha-1; Signal-regulatory protein alpha-2; Sirp-alpha-2; Signal-regulatory protein alpha-3; Sirp-alpha-3

Target 2

CEA

Gene ID

1048

UniProt ID

A0A024R0K5

Alternative Names

CEACAM5; carcinoembryonic antigen-related cell adhesion molecule 5; CEA; Carcinoembryonic antigen; CD66e; meconium antigen 100

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-SIRPα x Anti-CEA Bispecific Antibody (Tandem scFv) (CAT#: KN-1025-N27)

Specifications

Targets

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