Name: Recombinant Human Anti-SIRPα x Anti-HER2 Bispecific Antibody (Tandem scFv)
SKU: KN-1025-N37
Rating: 5 (1 reviews)

Recombinant Anti-SIRPα x Anti-HER2 Bispecific Antibody (Tandem scFv) is designed to be expressed as a scFv from an anti-SIRPα antibody variable domains fused with a scFv from an anti-HER2 antibody variable domains. It contains a His-tag at the C/N terminus for affinity purification. The BsAb exits as monomer in reducing and non-reducing conditions. This BsAb can retarget macrophages to HER2+ tumor cells. It is designed for the research of Solid tumors therapy.

Datasheet INQUIRY

Specifications

Targets

SIRPα & HER2

Type

Tandem scFv

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Solid tumors

Host Animal 1

Human

Host Animal 2

Human

Targets

Target 1

SIRPα

Gene ID

140885

UniProt ID

P78324

Alternative Names

SHPS-1; CD172A; p84; MYD-1; BIT; PTPNS1; SIRPA; signal regulatory protein alpha; MFR; P84; MYD1; SIRP; SHPS1; Tyrosine-protein phosphatase non-receptor type substrate 1; SHP substrate 1; Brain Ig-like molecule with tyrosine-based activation motifs; CD172 antigen-like family member A; Inhibitory receptor SHPS-1; Macrophage fusion receptor; MyD-1 antigen; Signal-regulatory protein alpha-1; Sirp-alpha-1; Signal-regulatory protein alpha-2; Sirp-alpha-2; Signal-regulatory protein alpha-3; Sirp-alpha-3

Target 2

HER2

Gene ID

2064

UniProt ID

P04626

Alternative Names

ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-SIRPα x Anti-HER2 Bispecific Antibody (Tandem scFv) (CAT#: KN-1025-N37)

Specifications

Targets

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