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CA9 Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H295 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD55 Human CA9 Human Inquiry
T-BSDB-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD55 Mouse CA9 Mouse Inquiry
SCIGG-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (scIgG) Human Single chain IgGs CD55 Human CA9 Human Inquiry
SCIGG-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (scIgG) Human Single chain IgGs CD55 Mouse CA9 Mouse Inquiry
FVTIG-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD55 Human CA9 Human Inquiry
FVTIG-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD55 Mouse CA9 Mouse Inquiry
BSSG-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (scFv-IgG) Human scFv-IgG CD55 Human CA9 Human Inquiry
BSSG-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (scFv-IgG) Human scFv-IgG CD55 Mouse CA9 Mouse Inquiry
IGLFV-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD55 Human CA9 Human Inquiry
IGLFV-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD55 Mouse CA9 Mouse Inquiry
BSGV-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD55 Mouse CA9 Mouse Inquiry
BSGV-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD55 Mouse CA9 Mouse Inquiry
BSDG-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (Fv-IgG) Human Fv-IgG CD55 Human CA9 Human Inquiry
BSDG-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (Fv-IgG) Human Fv-IgG CD55 Mouse CA9 Mouse Inquiry
BABFV-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD55 Human CA9 Human Inquiry
BABFV-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD55 Mouse CA9 Mouse Inquiry
FABVC-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD55 Human CA9 Human Inquiry
FABVC-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD55 Mouse CA9 Mouse Inquiry
SCDBC-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD55 Human CA9 Human Inquiry
SCDBC-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD55 Mouse CA9 Mouse Inquiry
BSDBC-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD55 Human CA9 Human Inquiry
BSDBC-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD55 Mouse CA9 Mouse Inquiry
SCDBF-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD55 Human CA9 Human Inquiry
SCDBF-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD55 Mouse CA9 Mouse Inquiry
BSFVF-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD55 Human CA9 Human Inquiry
BSFVF-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD55 Mouse CA9 Mouse Inquiry
BSDBF-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD55 Human CA9 Human Inquiry
BSDBF-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD55 Mouse CA9 Mouse Inquiry
BSTF-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD55 Mouse CA9 Mouse Inquiry
BSTF-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD55 Mouse CA9 Mouse Inquiry
BSCFV-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD55 Mouse CA9 Mouse Inquiry
BSCFV-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD55 Mouse CA9 Mouse Inquiry
MNAB-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (Miniantibody) Human Miniantibody CD55 Mouse CA9 Mouse Inquiry
MNAB-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (Miniantibody) Human Miniantibody CD55 Mouse CA9 Mouse Inquiry
BSFC-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD55 Mouse CA9 Mouse Inquiry
BSFC-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD55 Mouse CA9 Mouse Inquiry
BSCC-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD55 Mouse CA9 Mouse Inquiry
BSCC-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD55 Mouse CA9 Mouse Inquiry
BIBD-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (Bibody) Human Bibody CD55 Mouse CA9 Mouse Inquiry
BIBD-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (Bibody) Human Bibody CD55 Mouse CA9 Mouse Inquiry
FABFV-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD55 Human CA9 Human Inquiry
FABFV-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD55 Mouse CA9 Mouse Inquiry
MiniB-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (Minibody) Human Minibody CD55 Human CA9 Human Inquiry
MiniB-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (Minibody) Human Minibody CD55 Mouse CA9 Mouse Inquiry
SCTB-H186 Recombinant Human Anti-CA9 x Human Anti-CD55 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD55 Human CA9 Human Inquiry
SCDB-H295 Recombinant Human Anti-CD55 x Anti-CA9 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD55 Human CA9 Human Inquiry
FABIG-H295 Recombinant Human Anti-CD55 x Anti-CA9 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD55 Human CA9 Human Inquiry
TRIB-H297 Recombinant Human Anti-CD55 x Anti-CA9 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD55 Human CA9 Human Inquiry
BSIG-H295 Human Anti-CD55 x Anti-CA9 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD55 Human CA9 Human Inquiry
CROSSAB-H295 Recombinant Human Anti-CD55 x Anti-CA9 Bispecific Antibody (CrossMab) Human CrossMab CD55 Human CA9 Human Inquiry
IGFV-H295 Recombinant Human Anti-CD55 x Anti-CA9 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD55 Human CA9 Human Inquiry
BSDB-H295 Recombinant Human Anti-CD55 x Anti-CA9 Bispecific Antibody (Diabody) Human Diabody CD55 Human CA9 Human Inquiry
BSFAB-H295 Recombinant Human Anti-CD55 x Anti-CA9 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD55 Human CA9 Human Inquiry
BSFV-H295 Recombinant Human Anti-CD55 x Anti-CA9 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD55 Human CA9 Human Inquiry
SCTB-091 Recombinant Anti-CA9 x Anti-CD55 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD55 Mouse CA9 Mouse Inquiry
SCDB-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD55 Mouse CA9 Mouse Inquiry
FABIG-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD55 Mouse CA9 Mouse Inquiry
TRIB-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD55 Mouse CA9 Mouse Inquiry
BSIG-123 Anti-CD55 x Anti-CA9 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD55 Mouse CA9 Mouse Inquiry
CROSSAB-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (CrossMab) Human CrossMab CD55 Mouse CA9 Mouse Inquiry
IGFV-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD55 Mouse CA9 Mouse Inquiry
BSDB-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (Diabody) Human Diabody CD55 Mouse CA9 Mouse Inquiry
BSFAB-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD55 Mouse CA9 Mouse Inquiry
BSFV-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD55 Mouse CA9 Mouse Inquiry

Background

The CA IX role in pH regulation in hypoxic cancer cells. (Pastorekova and Robert, 2019) Fig.1 The CA IX role in pH
regulation in hypoxic cancer cells.1

Carbonic anhydrase 9 (CA9), also known as carbonic anhydrase IX, is an enzyme that plays a crucial role in regulating pH balance and acid-base homeostasis in various tissues. CA9 can catalyze the reversible transformation of protons (H+) and bicarbonate ions (HCO3-) into carbon dioxide (CO2) and water (H2O). This enzymatic activity helps to regulate pH by maintaining the balance between CO2 and bicarbonate ions in tissues and bodily fluids. CA9 has significant application fields in cancer research and treatment. Its overexpression is commonly observed in solid tumors, particularly in regions with limited oxygen supply. Thus, CA9 is a target for imaging methods like positron emission tomography (PET), allowing the detection and monitoring of hypoxic tumor regions. Additionally, CA9 inhibitors are being investigated as potential therapeutic agents for cancer treatment, as blocking CA9 activity can disrupt tumor cell survival and growth in the hypoxic microenvironment.

Reference

  1. Pastorekova, Silvia, and Robert J Gillies. “The role of carbonic anhydrase IX in cancer development: links to hypoxia, acidosis, and beyond.” Cancer metastasis reviews vol. 38,1-2 (2019): 65-77.
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