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CD74 Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H243 Recombinant Human Anti-CD3 x Human Anti-CD74 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Human CD74 Human Inquiry
T-BSDB-069 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Mouse CD74 Mouse Inquiry
SCIGG-H245 Recombinant Human Anti-CD3 x Human Anti-CD74 Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Human CD74 Human Inquiry
FABVC-370 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (Fab-sdAb-Fc) Human Fab-scFv/sdAb-Fc CD3 Mouse CD74 llama Inquiry
BSSG-370 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (sdAb-IgG) Human sdAb-IgG CD3 Mouse CD74 llama Inquiry
HCAB-015 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (sdAb-Fc-sdAb) Human sdAb-Fc-sdAb CD3 llama CD74 llama Inquiry
BIBD-370 Recombinant Anti-CD3 x Anti-CD74 VHH BispecificAntibody (Bibody) Human Bibody CD3 Mouse CD74 llama Inquiry
IGVHH-015 Recombinant Anti-CD3 x Anti-CD74 sdAb Bispecific Antibody (IgG-sdAb) Human IgG-sdAb CD3 Mouse CD74 llama Inquiry
BIVHH-015 Recombinant Anti-CD3 sdAb x Anti-CD74 sdAb Bispecific Antibody (Bi-sdAb) Human Bi-sdAb CD3 llama CD74 llama Inquiry
SCIGG-069 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Mouse CD74 Mouse Inquiry
FVTIG-H245 Recombinant Human Anti-CD3 x Human Anti-CD74 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Human CD74 Human Inquiry
FVTIG-069 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Mouse CD74 Mouse Inquiry
BSSG-H245 Recombinant Human Anti-CD3 x Human Anti-CD74 Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Human CD74 Human Inquiry
BSSG-069 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Mouse CD74 Mouse Inquiry
IGLFV-H245 Recombinant Human Anti-CD3 x Human Anti-CD74 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Human CD74 Human Inquiry
IGLFV-069 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Mouse CD74 Mouse Inquiry
BSGV-H245 Recombinant Human Anti-CD3 x Human Anti-CD74 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Mouse CD74 Mouse Inquiry
BSGV-069 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Mouse CD74 Mouse Inquiry
BSDG-H245 Recombinant Human Anti-CD3 x Human Anti-CD74 Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Human CD74 Human Inquiry
BSDG-069 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Mouse CD74 Mouse Inquiry
BABFV-H245 Recombinant Human Anti-CD3 x Human Anti-CD74 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Human CD74 Human Inquiry
BABFV-069 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Mouse CD74 Mouse Inquiry
FABVC-H245 Recombinant Human Anti-CD3 x Human Anti-CD74 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Human CD74 Human Inquiry
FABVC-069 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Mouse CD74 Mouse Inquiry
SCDBC-H245 Recombinant Human Anti-CD3 x Human Anti-CD74 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Human CD74 Human Inquiry
SCDBC-069 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Mouse CD74 Mouse Inquiry
BSDBC-H245 Recombinant Human Anti-CD3 x Human Anti-CD74 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Human CD74 Human Inquiry
BSDBC-069 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Mouse CD74 Mouse Inquiry
SCDBF-H245 Recombinant Human Anti-CD3 x Human Anti-CD74 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Human CD74 Human Inquiry
SCDBF-069 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Mouse CD74 Mouse Inquiry
BSFVF-H245 Recombinant Human Anti-CD3 x Human Anti-CD74 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Human CD74 Human Inquiry
BSFVF-069 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Mouse CD74 Mouse Inquiry
BSDBF-H245 Recombinant Human Anti-CD3 x Human Anti-CD74 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Human CD74 Human Inquiry
BSDBF-069 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Mouse CD74 Mouse Inquiry
BSTF-H245 Recombinant Human Anti-CD3 x Human Anti-CD74 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse CD74 Mouse Inquiry
BSTF-069 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse CD74 Mouse Inquiry
BSCFV-H245 Recombinant Human Anti-CD3 x Human Anti-CD74 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse CD74 Mouse Inquiry
BSCFV-069 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse CD74 Mouse Inquiry
MNAB-H245 Recombinant Human Anti-CD3 x Human Anti-CD74 Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse CD74 Mouse Inquiry
MNAB-069 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse CD74 Mouse Inquiry
BSFC-H245 Recombinant Human Anti-CD3 x Human Anti-CD74 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse CD74 Mouse Inquiry
BSFC-069 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse CD74 Mouse Inquiry
BSCC-H245 Recombinant Human Anti-CD3 x Human Anti-CD74 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse CD74 Mouse Inquiry
BSCC-069 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse CD74 Mouse Inquiry
BIBD-H245 Recombinant Human Anti-CD3 x Human Anti-CD74 Bispecific Antibody (Bibody) Human Bibody CD3 Mouse CD74 Mouse Inquiry
BIBD-069 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (Bibody) Human Bibody CD3 Mouse CD74 Mouse Inquiry
FABFV-H245 Recombinant Human Anti-CD3 x Human Anti-CD74 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Human CD74 Human Inquiry
FABFV-069 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Mouse CD74 Mouse Inquiry
MiniB-H245 Recombinant Human Anti-CD3 x Human Anti-CD74 Bispecific Antibody (Minibody) Human Minibody CD3 Human CD74 Human Inquiry
MiniB-069 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (Minibody) Human Minibody CD3 Mouse CD74 Mouse Inquiry
SCTB-H139 Recombinant Human Anti-CD74 x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Human CD74 Human Inquiry
SCDB-H243 Recombinant Human Anti-CD3 x Anti-CD74 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Human CD74 Human Inquiry
FABIG-H243 Recombinant Human Anti-CD3 x Anti-CD74 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Human CD74 Human Inquiry
TRIB-H245 Recombinant Human Anti-CD3 x Anti-CD74 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Human CD74 Human Inquiry
BSIG-H243 Human Anti-CD3 x Anti-CD74 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Human CD74 Human Inquiry
CROSSAB-H243 Recombinant Human Anti-CD3 x Anti-CD74 Bispecific Antibody (CrossMab) Human CrossMab CD3 Human CD74 Human Inquiry
IGFV-H243 Recombinant Human Anti-CD3 x Anti-CD74 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human CD74 Human Inquiry
BSDB-H243 Recombinant Human Anti-CD3 x Anti-CD74 Bispecific Antibody (Diabody) Human Diabody CD3 Human CD74 Human Inquiry
BSFAB-H243 Recombinant Human Anti-CD3 x Anti-CD74 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Human CD74 Human Inquiry
BSFV-H243 Recombinant Human Anti-CD3 x Anti-CD74 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Human CD74 Human Inquiry
SCTB-041 Recombinant Anti-CD74 x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Mouse CD74 Mouse Inquiry
SCDB-069 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Mouse CD74 Mouse Inquiry
FABIG-069 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse CD74 Mouse Inquiry
TRIB-069 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse CD74 Mouse Inquiry
BSIG-069 Anti-CD3 x Anti-CD74 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse CD74 Mouse Inquiry
CROSSAB-069 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse CD74 Mouse Inquiry
IGFV-069 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse CD74 Mouse Inquiry
BSDB-069 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (Diabody) Human Diabody CD3 Mouse CD74 Mouse Inquiry
BSFAB-069 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse CD74 Mouse Inquiry
BSFV-069 Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse CD74 Mouse Inquiry

Background

Leukocyte differentiation antigen 74 (CD74) is a type II transmembrane protein. It is the receptor for the cytokine, macrophage migration inhibitory factor (MIF), with the participation of CD44 as the signal transducer in a two-component MIF receptor complex. CD74 can also regulate the transport of angiotensin II type I receptor (AT1) and is a functional receptor for tissue inhibitor of metalloproteinase-1 (TIMP-1). It serves as a molecular chaperone for MHC class II molecules, participating in the folding of MHC class II molecules, intracellular transport, and loading of antigenic peptides. Stimulation of CD74 also triggered the activation of pathways that play a critical role in cell proliferation and survival, including the AMP-activated protein kinase (AMPK) pathway and the NF-κB and PI3K-Akt signal transduction cascades. CD74 also regulates cytoplasmic calcium homeostasis and plays a regulatory role in arrhythmia. The high expression characteristics of CD74 in atherosclerosis and acute myocardial infarction, as well as the rapid endocytosis of CD74, provide an important basis for precise targeted treatment of CD74.

Fig.1 Primary functions of CD74. (Li, 2023) Fig.1 Primary functions of CD74.1

Reference

  1. Li, Qiu-Lin, et al. "The role of CD74 in cardiovascular disease." Frontiers in Cardiovascular Medicine 9 (2023): 1049143.
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