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Csl Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H311 Recombinant Human Anti-Csl x Human Anti-CD3 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody Csl Human CD3 Human Inquiry
T-BSDB-144 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody Csl Mouse CD3 Mouse Inquiry
SCIGG-H313 Recombinant Human Anti-Csl x Human Anti-CD3 Bispecific Antibody (scIgG) Human Single chain IgGs Csl Human CD3 Human Inquiry
SCIGG-144 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (scIgG) Human Single chain IgGs Csl Mouse CD3 Mouse Inquiry
FVTIG-H313 Recombinant Human Anti-Csl x Human Anti-CD3 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig Csl Human CD3 Human Inquiry
FVTIG-144 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig Csl Mouse CD3 Mouse Inquiry
BSSG-H313 Recombinant Human Anti-Csl x Human Anti-CD3 Bispecific Antibody (scFv-IgG) Human scFv-IgG Csl Human CD3 Human Inquiry
BSSG-144 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (scFv-IgG) Human scFv-IgG Csl Mouse CD3 Mouse Inquiry
IGLFV-H313 Recombinant Human Anti-Csl x Human Anti-CD3 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv Csl Human CD3 Human Inquiry
IGLFV-144 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv Csl Mouse CD3 Mouse Inquiry
BSGV-H313 Recombinant Human Anti-Csl x Human Anti-CD3 Bispecific Antibody (IgG-Fv) Human IgG-Fv Csl Mouse CD3 Mouse Inquiry
BSGV-144 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (IgG-Fv) Human IgG-Fv Csl Mouse CD3 Mouse Inquiry
BSDG-H313 Recombinant Human Anti-Csl x Human Anti-CD3 Bispecific Antibody (Fv-IgG) Human Fv-IgG Csl Human CD3 Human Inquiry
BSDG-144 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (Fv-IgG) Human Fv-IgG Csl Mouse CD3 Mouse Inquiry
BABFV-H313 Recombinant Human Anti-Csl x Human Anti-CD3 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 Csl Human CD3 Human Inquiry
BABFV-144 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 Csl Mouse CD3 Mouse Inquiry
FABVC-H313 Recombinant Human Anti-Csl x Human Anti-CD3 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc Csl Human CD3 Human Inquiry
FABVC-144 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc Csl Mouse CD3 Mouse Inquiry
SCDBC-H313 Recombinant Human Anti-Csl x Human Anti-CD3 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 Csl Human CD3 Human Inquiry
SCDBC-144 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 Csl Mouse CD3 Mouse Inquiry
BSDBC-H313 Recombinant Human Anti-Csl x Human Anti-CD3 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 Csl Human CD3 Human Inquiry
BSDBC-144 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 Csl Mouse CD3 Mouse Inquiry
SCDBF-H313 Recombinant Human Anti-Csl x Human Anti-CD3 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc Csl Human CD3 Human Inquiry
SCDBF-144 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc Csl Mouse CD3 Mouse Inquiry
BSFVF-H313 Recombinant Human Anti-Csl x Human Anti-CD3 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc Csl Human CD3 Human Inquiry
BSFVF-144 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc Csl Mouse CD3 Mouse Inquiry
BSDBF-H313 Recombinant Human Anti-Csl x Human Anti-CD3 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc Csl Human CD3 Human Inquiry
BSDBF-144 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc Csl Mouse CD3 Mouse Inquiry
BSTF-H313 Recombinant Human Anti-Csl x Human Anti-CD3 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv Csl Mouse CD3 Mouse Inquiry
BSTF-144 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv Csl Mouse CD3 Mouse Inquiry
BSCFV-H313 Recombinant Human Anti-Csl x Human Anti-CD3 Bispecific Antibody (scFv-Fc) Human scFv-Fc Csl Mouse CD3 Mouse Inquiry
BSCFV-144 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (scFv-Fc) Human scFv-Fc Csl Mouse CD3 Mouse Inquiry
MNAB-H313 Recombinant Human Anti-Csl x Human Anti-CD3 Bispecific Antibody (Miniantibody) Human Miniantibody Csl Mouse CD3 Mouse Inquiry
MNAB-144 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (Miniantibody) Human Miniantibody Csl Mouse CD3 Mouse Inquiry
BSFC-H313 Recombinant Human Anti-Csl x Human Anti-CD3 Bispecific Antibody (scFv-CH3) Human scFv-CH3 Csl Mouse CD3 Mouse Inquiry
BSFC-144 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (scFv-CH3) Human scFv-CH3 Csl Mouse CD3 Mouse Inquiry
BSCC-H313 Recombinant Human Anti-Csl x Human Anti-CD3 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL Csl Mouse CD3 Mouse Inquiry
BSCC-144 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL Csl Mouse CD3 Mouse Inquiry
BIBD-H313 Recombinant Human Anti-Csl x Human Anti-CD3 Bispecific Antibody (Bibody) Human Bibody Csl Mouse CD3 Mouse Inquiry
BIBD-144 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (Bibody) Human Bibody Csl Mouse CD3 Mouse Inquiry
FABFV-H313 Recombinant Human Anti-Csl x Human Anti-CD3 Bispecific Antibody (Fab-Fv) Human Fab-Fv Csl Human CD3 Human Inquiry
FABFV-144 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (Fab-Fv) Human Fab-Fv Csl Mouse CD3 Mouse Inquiry
MiniB-H313 Recombinant Human Anti-Csl x Human Anti-CD3 Bispecific Antibody (Minibody) Human Minibody Csl Human CD3 Human Inquiry
MiniB-144 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (Minibody) Human Minibody Csl Mouse CD3 Mouse Inquiry
SCTB-H144 Recombinant Human Anti-Csl x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody Csl Human CD3 Human Inquiry
SCDB-H311 Recombinant Human Anti-Csl x Anti-CD3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Csl Human CD3 Human Inquiry
FABIG-H311 Recombinant Human Anti-Csl x Anti-CD3 Bispecific Antibody (Fab-IgG) Human Fab-IgG Csl Human CD3 Human Inquiry
TRIB-H313 Recombinant Human Anti-Csl x Anti-CD3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv Csl Human CD3 Human Inquiry
BSIG-H311 Human Anti-Csl x Anti-CD3 Bispecific Antibody (IgG-IgG) Human IgG-IgG Csl Human CD3 Human Inquiry
CROSSAB-H311 Recombinant Human Anti-Csl x Anti-CD3 Bispecific Antibody (CrossMab) Human CrossMab Csl Human CD3 Human Inquiry
IGFV-H311 Recombinant Human Anti-Csl x Anti-CD3 Bispecific Antibody (IgG-scFv) Human IgG-scFv Csl Human CD3 Human Inquiry
BSDB-H311 Recombinant Human Anti-Csl x Anti-CD3 Bispecific Antibody (Diabody) Human Diabody Csl Human CD3 Human Inquiry
BSFAB-H311 Recombinant Human Anti-Csl x Anti-CD3 Bispecific Antibody (Tandem Fab) Human Tandem Fab Csl Human CD3 Human Inquiry
BSFV-H311 Recombinant Human Anti-Csl x Anti-CD3 Bispecific Antibody (Tandem scFv) Human Tandem scFv Csl Human CD3 Human Inquiry
SCTB-046 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody Csl Mouse CD3 Mouse Inquiry
SCDB-144 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Csl Mouse CD3 Mouse Inquiry
FABIG-144 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (Fab-IgG) Human Fab-IgG Csl Mouse CD3 Mouse Inquiry
TRIB-144 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv Csl Mouse CD3 Mouse Inquiry
BSIG-144 Anti-Csl x Anti-CD3 Bispecific Antibody (IgG-IgG) Human IgG-IgG Csl Mouse CD3 Mouse Inquiry
CROSSAB-144 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (CrossMab) Human CrossMab Csl Mouse CD3 Mouse Inquiry
IGFV-144 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (IgG-scFv) Human IgG-scFv Csl Mouse CD3 Mouse Inquiry
BSDB-144 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (Diabody) Human Diabody Csl Mouse CD3 Mouse Inquiry
BSFAB-144 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (Tandem Fab) Human Tandem Fab Csl Mouse CD3 Mouse Inquiry
BSFV-144 Recombinant Anti-Csl x Anti-CD3 Bispecific Antibody (Tandem scFv) Human Tandem scFv Csl Mouse CD3 Mouse Inquiry

Background

Csl, alias Recombination Signal Binding Protein for Immunoglobulin Kappa J Region (RBPJ), functions as a pivotal transcriptional regulator in the Notch signaling pathway, featuring three domains—the C-terminal domain (CTD), the N-terminal domain (NTD) and the trefoil domain (BTD). CSL facilitates interactions with coactivators and corepressors. Serving as a repressor in the absence of Notch protein binding, CSL engages corepressor proteins. On the contrary, csl functions as a stimulator upon binding with Notch proteins. Its proposed mechanism involves enlisting chromatin-modifying complexes housing proteins like histone deacetylases or histone acetylases to target genes in the Notch signaling pathway.

Csl's involvement in Notch signaling: unveiling its role and structural features. (Tabaja, et al., 2017) Fig.1 Csl's involvement in Notch signaling: unveiling its role and structural features.1

Reference

  1. Tabaja, Nassif, et al. "Structure-function analysis of RBP-J-interacting and tubulin-associated (RITA) reveals regions critical for repression of Notch target genes." Journal of Biological Chemistry 292.25 (2017): 10549-10563.
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