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FcRH5 Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H255 Recombinant Human Anti-CD3 x Human Anti-FcRH5 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Human FcRH5 Human Inquiry
T-BSDB-081 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Mouse FcRH5 Mouse Inquiry
KN-0422-LN11 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (BsIgG) Human BsIgG CD3 Human FcRH5 Human Inquiry
SCIGG-H257 Recombinant Human Anti-CD3 x Human Anti-FcRH5 Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Human FcRH5 Human Inquiry
SCIGG-081 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Mouse FcRH5 Mouse Inquiry
FVTIG-H257 Recombinant Human Anti-CD3 x Human Anti-FcRH5 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Human FcRH5 Human Inquiry
FVTIG-081 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Mouse FcRH5 Mouse Inquiry
BSSG-H257 Recombinant Human Anti-CD3 x Human Anti-FcRH5 Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Human FcRH5 Human Inquiry
BSSG-081 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Mouse FcRH5 Mouse Inquiry
IGLFV-H257 Recombinant Human Anti-CD3 x Human Anti-FcRH5 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Human FcRH5 Human Inquiry
IGLFV-081 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Mouse FcRH5 Mouse Inquiry
BSGV-H257 Recombinant Human Anti-CD3 x Human Anti-FcRH5 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Mouse FcRH5 Mouse Inquiry
BSGV-081 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Mouse FcRH5 Mouse Inquiry
BSDG-H257 Recombinant Human Anti-CD3 x Human Anti-FcRH5 Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Human FcRH5 Human Inquiry
BSDG-081 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Mouse FcRH5 Mouse Inquiry
BABFV-H257 Recombinant Human Anti-CD3 x Human Anti-FcRH5 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Human FcRH5 Human Inquiry
BABFV-081 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Mouse FcRH5 Mouse Inquiry
FABVC-H257 Recombinant Human Anti-CD3 x Human Anti-FcRH5 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Human FcRH5 Human Inquiry
FABVC-081 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Mouse FcRH5 Mouse Inquiry
SCDBC-H257 Recombinant Human Anti-CD3 x Human Anti-FcRH5 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Human FcRH5 Human Inquiry
SCDBC-081 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Mouse FcRH5 Mouse Inquiry
BSDBC-H257 Recombinant Human Anti-CD3 x Human Anti-FcRH5 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Human FcRH5 Human Inquiry
BSDBC-081 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Mouse FcRH5 Mouse Inquiry
SCDBF-H257 Recombinant Human Anti-CD3 x Human Anti-FcRH5 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Human FcRH5 Human Inquiry
SCDBF-081 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Mouse FcRH5 Mouse Inquiry
BSFVF-H257 Recombinant Human Anti-CD3 x Human Anti-FcRH5 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Human FcRH5 Human Inquiry
BSFVF-081 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Mouse FcRH5 Mouse Inquiry
BSDBF-H257 Recombinant Human Anti-CD3 x Human Anti-FcRH5 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Human FcRH5 Human Inquiry
BSDBF-081 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Mouse FcRH5 Mouse Inquiry
BSTF-H257 Recombinant Human Anti-CD3 x Human Anti-FcRH5 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse FcRH5 Mouse Inquiry
BSTF-081 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse FcRH5 Mouse Inquiry
BSCFV-H257 Recombinant Human Anti-CD3 x Human Anti-FcRH5 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse FcRH5 Mouse Inquiry
BSCFV-081 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse FcRH5 Mouse Inquiry
MNAB-H257 Recombinant Human Anti-CD3 x Human Anti-FcRH5 Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse FcRH5 Mouse Inquiry
MNAB-081 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse FcRH5 Mouse Inquiry
BSFC-H257 Recombinant Human Anti-CD3 x Human Anti-FcRH5 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse FcRH5 Mouse Inquiry
BSFC-081 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse FcRH5 Mouse Inquiry
BSCC-H257 Recombinant Human Anti-CD3 x Human Anti-FcRH5 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse FcRH5 Mouse Inquiry
BSCC-081 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse FcRH5 Mouse Inquiry
BIBD-H257 Recombinant Human Anti-CD3 x Human Anti-FcRH5 Bispecific Antibody (Bibody) Human Bibody CD3 Mouse FcRH5 Mouse Inquiry
BIBD-081 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (Bibody) Human Bibody CD3 Mouse FcRH5 Mouse Inquiry
FABFV-H257 Recombinant Human Anti-CD3 x Human Anti-FcRH5 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Human FcRH5 Human Inquiry
FABFV-081 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Mouse FcRH5 Mouse Inquiry
MiniB-H257 Recombinant Human Anti-CD3 x Human Anti-FcRH5 Bispecific Antibody (Minibody) Human Minibody CD3 Human FcRH5 Human Inquiry
MiniB-081 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (Minibody) Human Minibody CD3 Mouse FcRH5 Mouse Inquiry
SCTB-H152 Recombinant Human Anti-FcRH5 x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Human FcRH5 Human Inquiry
SCDB-H255 Recombinant Human Anti-CD3 x Anti-FcRH5 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Human FcRH5 Human Inquiry
FABIG-H255 Recombinant Human Anti-CD3 x Anti-FcRH5 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Human FcRH5 Human Inquiry
TRIB-H257 Recombinant Human Anti-CD3 x Anti-FcRH5 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Human FcRH5 Human Inquiry
BSIG-H255 Human Anti-CD3 x Anti-FcRH5 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Human FcRH5 Human Inquiry
CROSSAB-H255 Recombinant Human Anti-CD3 x Anti-FcRH5 Bispecific Antibody (CrossMab) Human CrossMab CD3 Human FcRH5 Human Inquiry
IGFV-H255 Recombinant Human Anti-CD3 x Anti-FcRH5 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human FcRH5 Human Inquiry
BSDB-H255 Recombinant Human Anti-CD3 x Anti-FcRH5 Bispecific Antibody (Diabody) Human Diabody CD3 Human FcRH5 Human Inquiry
BSFAB-H255 Recombinant Human Anti-CD3 x Anti-FcRH5 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Human FcRH5 Human Inquiry
BSFV-H255 Recombinant Human Anti-CD3 x Anti-FcRH5 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Human FcRH5 Human Inquiry
SCTB-054 Recombinant Anti-FcRH5 x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Mouse FcRH5 Mouse Inquiry
SCDB-081 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Mouse FcRH5 Mouse Inquiry
FABIG-081 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse FcRH5 Mouse Inquiry
TRIB-081 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse FcRH5 Mouse Inquiry
BSIG-081 Anti-CD3 x Anti-FcRH5 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse FcRH5 Mouse Inquiry
CROSSAB-081 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse FcRH5 Mouse Inquiry
IGFV-081 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse FcRH5 Mouse Inquiry
BSDB-081 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (Diabody) Human Diabody CD3 Mouse FcRH5 Mouse Inquiry
BSFAB-081 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse FcRH5 Mouse Inquiry
BSFV-081 Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse FcRH5 Mouse Inquiry

Background

CD307, with high sequence homology, is recognized as an Fc receptor and named Fc Receptor Homolog 5 (FcRH5). The expression of FcRH5 is predominately distributed among mature B cells and plasma cells, with a pronouncedly higher expression level observed on malignant plasma cells.

Although the conventional physiological role of FcRH5 is yet to be thoroughly elucidated, empirical studies indicate that it provides tyrosine-based immunoregulation and signal transduction, exerting an inhibitory effect on B Cell Receptor (BCR) activation and the consequent calcium signal transmission. These pieces of evidence collectively imply an exclusive role of FcRH5 in modulating the mobilization of B cells, which are instrumental in primary humoral immunity.

BCR and FCRL5 signaling. (Davis, 2015) Fig.1 BCR and FCRL5 signaling.1

Reference

  1. Davis. " FCRL regulation in innate-like B cells." Annals of The New York Academy of Science. 1362 (2015): 110-116.
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