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HER3 Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
BSFV-MEL031 Recombinant Human Anti-HER1 x Human Anti-HER3 Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Human HER3 Human Inquiry
BSFV-MEL028 Recombinant Human Anti-EGFR x Human Anti-HER3 Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Human HER3 Human Inquiry
BSFV-MEL016 Recombinant Anti-HER3 x Anti-IGF1R Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFV-MEL015 Recombinant Anti-HER2 x Anti-HER3 Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER2 Mouse HER3 Mouse Inquiry
BSFV-MEL013 Recombinant Anti-HER1 x Anti-HER3 Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Mouse HER3 Mouse Inquiry
BSFV-MEL010 Recombinant Anti-EGFR x Anti-HER3 Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Mouse HER3 Mouse Inquiry
BSFV-BGN034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFV-BGN033 Recombinant Human Anti-HER2 x Human Anti-HER3 Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER2 Human HER3 Human Inquiry
BSFV-BGN031 Recombinant Human Anti-HER1 x Human Anti-HER3 Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Human HER3 Human Inquiry
BSFV-BGN028 Recombinant Human Anti-EGFR x Human Anti-HER3 Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Human HER3 Human Inquiry
BSFV-BGN016 Recombinant Anti-HER3 x Anti-IGF1R Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFV-BGN015 Recombinant Anti-HER2 x Anti-HER3 Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER2 Mouse HER3 Mouse Inquiry
BSFV-BGN013 Recombinant Anti-HER1 x Anti-HER3 Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Mouse HER3 Mouse Inquiry
BSFV-BGN010 Recombinant Anti-EGFR x Anti-HER3 Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Mouse HER3 Mouse Inquiry
BSFV-ABR034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFV-ABR033 Recombinant Human Anti-HER2 x Human Anti-HER3 Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER2 Human HER3 Human Inquiry
BSFV-ABR031 Recombinant Human Anti-HER1 x Human Anti-HER3 Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Human HER3 Human Inquiry
BSFV-ABR028 Recombinant Human Anti-EGFR x Human Anti-HER3 Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Human HER3 Human Inquiry
BSFV-ABR016 Recombinant Anti-HER3 x Anti-IGF1R Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFV-ABR015 Recombinant Anti-HER2 x Anti-HER3 Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER2 Mouse HER3 Mouse Inquiry
BSFV-ABR013 Recombinant Anti-HER1 x Anti-HER3 Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Mouse HER3 Mouse Inquiry
BSFV-ABR010 Recombinant Anti-EGFR x Anti-HER3 Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Mouse HER3 Mouse Inquiry
BSFV-PAP034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFV-PAP033 Recombinant Human Anti-HER2 x Human Anti-HER3 Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER2 Human HER3 Human Inquiry
BSFV-PAP031 Recombinant Human Anti-HER1 x Human Anti-HER3 Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Human HER3 Human Inquiry
BSFV-PAP028 Recombinant Human Anti-EGFR x Human Anti-HER3 Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Human HER3 Human Inquiry
BSFV-PAP016 Recombinant Anti-HER3 x Anti-IGF1R Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFV-PAP015 Recombinant Anti-HER2 x Anti-HER3 Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER2 Mouse HER3 Mouse Inquiry
BSFV-PAP013 Recombinant Anti-HER1 x Anti-HER3 Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Mouse HER3 Mouse Inquiry
BSFV-PAP010 Recombinant Anti-EGFR x Anti-HER3 Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Mouse HER3 Mouse Inquiry
SCDB-H333 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody HER3 Human IGF1R Human Inquiry
SCDB-H331 Recombinant Human Anti-HER2 x Anti-HER3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody HER2 Human HER3 Human Inquiry
SCDB-H329 Recombinant Human Anti-HER1 x Anti-HER3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody HER1 Human HER3 Human Inquiry
SCDB-H322 Recombinant Human Anti-EGFR x Anti-HER3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody EGFR Human HER3 Human Inquiry
FABIG-H333 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (Fab-IgG) Human Fab-IgG HER3 Human IGF1R Human Inquiry
FABIG-H331 Recombinant Human Anti-HER2 x Anti-HER3 Bispecific Antibody (Fab-IgG) Human Fab-IgG HER2 Human HER3 Human Inquiry
FABIG-H329 Recombinant Human Anti-HER1 x Anti-HER3 Bispecific Antibody (Fab-IgG) Human Fab-IgG HER1 Human HER3 Human Inquiry
FABIG-H322 Recombinant Human Anti-EGFR x Anti-HER3 Bispecific Antibody (Fab-IgG) Human Fab-IgG EGFR Human HER3 Human Inquiry
TRIB-H335 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv HER3 Human IGF1R Human Inquiry
TRIB-H333 Recombinant Human Anti-HER2 x Anti-HER3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv HER2 Human HER3 Human Inquiry
TRIB-H331 Recombinant Human Anti-HER1 x Anti-HER3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv HER1 Human HER3 Human Inquiry
TRIB-H324 Recombinant Human Anti-EGFR x Anti-HER3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv EGFR Human HER3 Human Inquiry
BSIG-H333 Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (IgG-IgG) Human IgG-IgG HER3 Human IGF1R Human Inquiry
BSIG-H331 Human Anti-HER2 x Anti-HER3 Bispecific Antibody (IgG-IgG) Human IgG-IgG HER2 Human HER3 Human Inquiry
BSIG-H329 Human Anti-HER1 x Anti-HER3 Bispecific Antibody (IgG-IgG) Human IgG-IgG HER1 Human HER3 Human Inquiry
BSIG-H322 Human Anti-EGFR x Anti-HER3 Bispecific Antibody (IgG-IgG) Human IgG-IgG EGFR Human HER3 Human Inquiry
CROSSAB-H333 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (CrossMab) Human CrossMab HER3 Human IGF1R Human Inquiry
CROSSAB-H331 Recombinant Human Anti-HER2 x Anti-HER3 Bispecific Antibody (CrossMab) Human CrossMab HER2 Human HER3 Human Inquiry
CROSSAB-H329 Recombinant Human Anti-HER1 x Anti-HER3 Bispecific Antibody (CrossMab) Human CrossMab HER1 Human HER3 Human Inquiry
CROSSAB-H322 Recombinant Human Anti-EGFR x Anti-HER3 Bispecific Antibody (CrossMab) Human CrossMab EGFR Human HER3 Human Inquiry
IGFV-H333 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (IgG-scFv) Human IgG-scFv HER3 Human IGF1R Human Inquiry
IGFV-H331 Recombinant Human Anti-HER2 x Anti-HER3 Bispecific Antibody (IgG-scFv) Human IgG-scFv HER2 Human HER3 Human Inquiry
IGFV-H329 Recombinant Human Anti-HER1 x Anti-HER3 Bispecific Antibody (IgG-scFv) Human IgG-scFv HER1 Human HER3 Human Inquiry
IGFV-H322 Recombinant Human Anti-EGFR x Anti-HER3 Bispecific Antibody (IgG-scFv) Human IgG-scFv EGFR Human HER3 Human Inquiry
BSDB-H333 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (Diabody) Human Diabody HER3 Human IGF1R Human Inquiry
BSDB-H331 Recombinant Human Anti-HER2 x Anti-HER3 Bispecific Antibody (Diabody) Human Diabody HER2 Human HER3 Human Inquiry
BSDB-H329 Recombinant Human Anti-HER1 x Anti-HER3 Bispecific Antibody (Diabody) Human Diabody HER1 Human HER3 Human Inquiry
BSDB-H322 Recombinant Human Anti-EGFR x Anti-HER3 Bispecific Antibody (Diabody) Human Diabody EGFR Human HER3 Human Inquiry
BSFAB-H333 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (Tandem Fab) Human Tandem Fab HER3 Human IGF1R Human Inquiry
BSFAB-H331 Recombinant Human Anti-HER2 x Anti-HER3 Bispecific Antibody (Tandem Fab) Human Tandem Fab HER2 Human HER3 Human Inquiry
BSFAB-H329 Recombinant Human Anti-HER1 x Anti-HER3 Bispecific Antibody (Tandem Fab) Human Tandem Fab HER1 Human HER3 Human Inquiry
BSFAB-H322 Recombinant Human Anti-EGFR x Anti-HER3 Bispecific Antibody (Tandem Fab) Human Tandem Fab EGFR Human HER3 Human Inquiry
BSFV-H331 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (Tandem scFv) Human Tandem scFv HER3 Human IGF1R Human Inquiry
BSFV-H329 Recombinant Human Anti-HER2 x Anti-HER3 Bispecific Antibody (Tandem scFv) Human Tandem scFv HER2 Human HER3 Human Inquiry
BSFV-H327 Recombinant Human Anti-HER1 x Anti-HER3 Bispecific Antibody (Tandem scFv) Human Tandem scFv HER1 Human HER3 Human Inquiry
BSFV-H320 Recombinant Human Anti-EGFR x Anti-HER3 Bispecific Antibody (Tandem scFv) Human Tandem scFv EGFR Human HER3 Human Inquiry
SCDB-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody HER3 Mouse IGF1R Mouse Inquiry
SCDB-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody HER2 Mouse HER3 Mouse Inquiry
SCDB-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody HER1 Mouse HER3 Mouse Inquiry
SCDB-156 Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody EGFR Mouse HER3 Mouse Inquiry
FABIG-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Fab-IgG) Human Fab-IgG HER3 Mouse IGF1R Mouse Inquiry
FABIG-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (Fab-IgG) Human Fab-IgG HER2 Mouse HER3 Mouse Inquiry
FABIG-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Fab-IgG) Human Fab-IgG HER1 Mouse HER3 Mouse Inquiry
FABIG-156 Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (Fab-IgG) Human Fab-IgG EGFR Mouse HER3 Mouse Inquiry
TRIB-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv HER3 Mouse IGF1R Mouse Inquiry
TRIB-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv HER2 Mouse HER3 Mouse Inquiry
TRIB-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv HER1 Mouse HER3 Mouse Inquiry
TRIB-156 Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv EGFR Mouse HER3 Mouse Inquiry
BSIG-169 Anti-HER3 x Anti-IGF1R Bispecific Antibody (IgG-IgG) Human IgG-IgG HER3 Mouse IGF1R Mouse Inquiry
BSIG-167 Anti-HER2 x Anti-HER3 Bispecific Antibody (IgG-IgG) Human IgG-IgG HER2 Mouse HER3 Mouse Inquiry
BSIG-165 Anti-HER1 x Anti-HER3 Bispecific Antibody (IgG-IgG) Human IgG-IgG HER1 Mouse HER3 Mouse Inquiry
BSIG-156 Anti-EGFR x Anti-HER3 Bispecific Antibody (IgG-IgG) Human IgG-IgG EGFR Mouse HER3 Mouse Inquiry
CROSSAB-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (CrossMab) Human CrossMab HER2 Mouse HER3 Mouse Inquiry
CROSSAB-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (CrossMab) Human CrossMab HER1 Mouse HER3 Mouse Inquiry
IGFV-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (IgG-scFv) Human IgG-scFv HER3 Mouse IGF1R Mouse Inquiry
IGFV-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (IgG-scFv) Human IgG-scFv HER2 Mouse HER3 Mouse Inquiry
IGFV-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (IgG-scFv) Human IgG-scFv HER1 Mouse HER3 Mouse Inquiry
IGFV-156 Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (IgG-scFv) Human IgG-scFv EGFR Mouse HER3 Mouse Inquiry
BSDB-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Diabody) Human Diabody HER3 Mouse IGF1R Mouse Inquiry
BSDB-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (Diabody) Human Diabody HER2 Mouse HER3 Mouse Inquiry
BSDB-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Diabody) Human Diabody HER1 Mouse HER3 Mouse Inquiry
BSDB-156 Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (Diabody) Human Diabody EGFR Mouse HER3 Mouse Inquiry
BSFAB-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Tandem Fab) Human Tandem Fab HER3 Mouse IGF1R Mouse Inquiry
BSFAB-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (Tandem Fab) Human Tandem Fab HER2 Mouse HER3 Mouse Inquiry
BSFAB-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Tandem Fab) Human Tandem Fab HER1 Mouse HER3 Mouse Inquiry
BSFAB-156 Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (Tandem Fab) Human Tandem Fab EGFR Mouse HER3 Mouse Inquiry
BSFV-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Tandem scFv) Human Tandem scFv HER3 Mouse IGF1R Mouse Inquiry
BSFV-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (Tandem scFv) Human Tandem scFv HER2 Mouse HER3 Mouse Inquiry
BSFV-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Tandem scFv) Human Tandem scFv HER1 Mouse HER3 Mouse Inquiry
BSFV-156 Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (Tandem scFv) Human Tandem scFv EGFR Mouse HER3 Mouse Inquiry

Background

HER3 dimerization and signaling cascade. (Haikala, Heidi M., et al., 2021) Fig.1 HER3 dimerization and signaling cascade.1

Human epidermal growth factor receptor 3 (HER3/ErbB3) is a member of the ErbB/HER receptor tyrosine kinase family. It shares structural similarities with several other members of the family (e.g., EGFR/HER1, HER2, and HER4). However, unlike these family members, HER3 is not able to activate by binding to ligands, which allow signals to be triggered. It is activated by the heterodimer and causes downstream C-terminal phosphorylation via another heterodimer receptor. HER3's preferred dimerization partners are EGFR and HER2, with a reduced affinity for HER4. Activated HER3 stimulates PI3K/AKT and MAPK signaling pathways, both of which are important in cell survival and proliferation. HER3 does not induce carcinogenesis on its own, although it is expressed and overexpressed in various cancers during disease progression and metastatic lesions. HER2-HER3 heterodimers exhibit the highest transforming potential of any HER family dimer. Given its high oncogenicity, HER3 plays a crucial role in HER2-mediated cancers, and targeting HER3 has therapeutic implications for cancers such as breast cancer.

Reference

  1. Haikala, Heidi M.; et al. Thirty years of HER3: from basic biology to therapeutic interventions. Clinical Cancer Research, 2021, 27(13): 3528-3539.
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