Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Calcitonin receptor like receptor |
| Gene Name | CALCRL |
| Uniprot | Q16602 (Human); Q9R1W5 (Mouse) |
| Synonym | CRLR; CGRPR; LMPHM8; calcitonin gene-related peptide type 1 receptor; CGRP type 1 receptor; calcitonin receptor-like |
| Background | Calcitonin receptor-like receptor (CRL) is a 7-transmembrane family B G protein-coupled receptor for calcitonin gene-related peptide (CGRP). This receptor shares 55% sequence identity with the calcitonin receptor (CTR). CRL is co-expressed with different receptor activity-modifying proteins (RAMPs), which are single-transmembrane accessory proteins regulating the activities of several G protein-coupled receptors. Three types of RAMPs exist in mammals: RAMP1, RAMP2, RAMP3. Co-expression of CRL with RAMP1 results in the in the CGRP receptor, whereas co-expression with RAMP2 or RAMP3 produces the receptor for adrenomedullin, another member of the CGRP family. Besides contributing to receptor specificity, RAMPs are also required for CRLR transportation from the endoplasmic reticulum to the plasma membrane. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX467 | NativeExtract™ Human CALCRL Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX3574K | MemDX™ Membrane Protein Human CALCRL Expressed in vitro E.coli expression system, Full Length of Mature Protein | E.coli cell-free | Full length | Detergent |
| MP0157X | MemDX™ Membrane Protein Human CALCRL (Calcitonin receptor like receptor) with GST-tag for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| MP0156X | MemDX™ Membrane Protein Human CALCRL (Calcitonin receptor like receptor without tag) for Antibody Discovery | Wheat germ cell-free | Full length | Liposome |
| Please for more products or customization | ||||
L***s: Technical support expedites protocol optimization.
06/May/2023
C***a: Tailored CALCRL variants (C-terminal tags, point mutations) delivered within 4 weeks.
23/Jan/2024
CALCRL Gene Therapy Development
We provide tailored solutions to meet your specific requirements. Please for more services.
AAV-Mediated CALCRL Transduction for Cardiovascular Pathologies
Creative Biolabs offers AAV-mediated CALCRL transduction services. Adeno-associated virus (AAV) vectors engineered for endothelial cell specificity enable targeted delivery of CALCRL transgenes to modulate vascular permeability and angiogenesis. This approach leverages the receptor's role in regulating adrenomedullin signaling, a critical pathway in hypertension and heart failure pathogenesis. Preclinical studies demonstrate that AAV9-driven CALCRL overexpression restores receptor density in ischemic tissues, improving hemodynamic outcomes in rodent models of pulmonary arterial hypertension. Creative Biolabs' expertise in cell-specific viral vector design ensures optimal tropism and transduction efficiency for such applications.
RNA Interference for CALCRL Expression Attenuation
Creative Biolabs offers RNA interference services for CALCRL expression attenuation. Short-hairpin RNA (shRNA) delivery via lipid nanoparticles selectively silences CALCRL in tumors overexpressing this receptor, effectively disrupting its oncogenic signaling crosstalk with RAMP1/2 complexes. For instance, CALCRL knockdown in glioblastoma models reduces invasiveness by impairing cAMP-dependent metastatic pathways. Creative Biolabs' proprietary shRNA libraries and in vivo delivery systems enable rapid validation of target-specific sequences, ensuring robust translational potential.
Gene Editing for CALCRL Loss-of-Function Mutations
Creative Biolabs offers gene editing services for CALCRL loss-of-function mutations. Precision editing of CALCRL allelic variants linked to hereditary angioedema has been achieved using ribonucleoprotein complexes. This method corrects aberrant receptor conformations, restoring ligand-binding capacity in patient-derived fibroblasts. By integrating RNA design with high-fidelity editing protocols, Creative Biolabs supports the development of mutation-agnostic therapies for genetic disorders.
Creative Biolabs offers comprehensive and innovative services to drive the development of CALCRL cell therapy. Please for more services.
CAR-T Cell Engineering for CALCRL-Positive Solid Tumors
Creative Biolabs offers CAR-T cell engineering services. CARs targeting CALCRL's extracellular domain enable T cells to recognize and eliminate receptor-overexpressing malignancies, such as pancreatic adenocarcinoma. In vitro cytotoxicity assays reveal >70% tumor cell lysis within 48 hours, highlighting the therapeutic promise of this approach. Creative Biolabs' immunofluorescence validation services ensure accurate detection of CALCRL surface expression, a critical step in patient stratification.
Mesenchymal Stem Cell (MSC) Secretome Modulation via CALCRL
Creative Biolabs offers MSC secretome modulation services. Genetically modified MSCs secreting CALCRL-binding peptides act as localized delivery vehicles for anti-inflammatory cytokines in arthritic joints. These cells exploit the receptor's ligand-trapping mechanism to prolong therapeutic payload retention, as evidenced by a 50% reduction in synovitis in murine models. Creative Biolabs' gene expression profiling and RNA sequencing services optimize MSC engineering protocols.
CALCRL-Specific Exosome Mimetics for Neuroprotection
Creative Biolabs offers CALCRL-specific exosome mimetics development services. Exosomes loaded with CALCRL agonists, such as adrenomedullin mimetics, mitigate neuronal apoptosis in stroke models by activating pro-survival ERK pathways. Our imaging techniques, including super-resolution microscopy, confirm exosome homing to CALCRL-enriched brain regions, enabling non-invasive therapeutic monitoring.
From vector design to functional validation, Creative Biolabs delivers end-to-end support for CALCRL-centric therapeutics. Our advanced genotyping, gene editing, and cell-based assay platforms are tailored to de-risk preclinical development. to transform exploratory concepts into clinical-stage candidates.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
