Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsCaveolae are designated as specialized small plasma-membrane subdomains that play critical cellular functions through the regulation of trafficking and signal transductions. It is proved that two essential protein families, membrane caveolins, and cytoplasmic cavin proteins, are required for the caveola formation. Caveolins are present in the majority of adherent, mammalian cells. There are three members for caveolin gene family in vertebrates, including CAV1, CAV2, and CAV3, encoding corresponding proteins caveolin-1, caveolin-2, and caveolin-3, respectively. All these members are membrane proteins with similar in structure, involving an N-terminal caveolin scaffolding domain (CSD), a transmembrane domain as well as a C-terminal domain. The CSD and C-terminal are sufficient for the caveolin attachment to cell membranes, even without a membrane-spanning domain. Caveolins form oligomers and correlate with cholesterol and sphingolipids in certain membrane areas, leading to the constitution of caveolae. Furthermore, caveolin has a paradoxical role in the development of oncogenesis. This protein is involved in cancer formation and suppression, which depends on the tumor type and progress stage.
The caveolin family consists of three type proteins, CAV1-3, and here shows part of caveolins. There exist two isoforms for CAV1, caveolin-1α and caveolin-1β, the latter lacking a part of the N-terminus. CAV1 is indispensable for the caveolae formation while CAV2 is not, whose expression and membrane localization rely on CAV1. CAV3 as a muscle-specific isoform is also required for the caveolae formation in cardiac and skeletal muscle cells.
Based on cutting-edge MemDX™ membrane protein production platform, Creative Biolabs would like to offer the preparation of these proteins in required formats by using diverse strategies, such as detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, stable cell line.
Remarkably, our MemDX™ membrane protein antibody discovery platform can assist to discover antibodies against these targets, even fully humanized antibodies, by various methods involving phage display technology, hybridoma technology, etc. Besides, we also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more details.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
