Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | C-C chemokine receptor type 9 |
| Gene Name | CCR9 |
| Uniprot | P51686 (Human); Q9WUT7 (Mouse) |
| Synonym | GPR28; CDw199; GPR-9-6; CC-CKR-9; C-C chemokine receptor type 9; G protein-coupled receptor 28 |
| Background | CCR-9, also known as cluster of differentiation w199 (CDw199), GPR28 or GPR-9-6, is a member of the beta chemokine receptor family, which in human is encoded by CCR9 gene. CCR-9 is supposed to be a seven transmembrane protein similar to G protein-coupled receptors. It is predominantly found in immature T lymphocytes and on the surface of intestinal cells. The specific ligand of CCR-9 has been identified to be CCL25 (also known as SCYA25 or TECK). |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX450 | NativeExtract™ Human CCR9 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MP1338J | MemDX™ Membrane Protein Human CCR9 (C-C motif chemokine receptor 9) expressed in E.coli for Antibody Discovery | E.colicell-free | Full length | Detergent |
| MP0174X | MemDX™ Membrane Protein Human CCR9 (C-C motif chemokine receptor 9) for Antibody Discovery | Wheat germ cell-free | Full length | Liposome |
| S01YF-0423-KX485 | MemDX™ Membrane Protein Human CCR9 (1-48aa) Expressed in HEK293, C-Human Fc tag | HEK293 cells | Partial | N/A |
| Please for more products or customization | ||||
F***st: The technical support team at Creative Biolabs was very knowledgeable and provided valuable advice on how to optimize the use of the protein for my particular application. I am very pleased with my purchase and will definitely consider them for future orders.
22/ Oct/2023
We provide tailored solutions to meet your specific requirements. Please for more services.
Creative Biolabs offers knockdown or inhibition of CCR9 expression services. Reducing CCR9 levels in disease-driving cells (e.g., inflammatory T cells in IBD or leukemic cells in T-ALL). Altering the receptor's ability to bind its ligand or initiate downstream signaling. Using CCR9 as a marker to specifically deliver therapeutic payloads to disease-relevant cells.
Creative Biolabs offers blocking CCR9/CCL25 interaction services. Since CCR9/CCL25 signaling plays a role in tumor progression, metastasis, and chemotherapy resistance, blocking this interaction can be a potential therapeutic strategy. Inhibiting the CCR9-induced cholesterol biosynthesis pathway with statins may pave the way for the development of effective therapeutic strategies to treat T-ALL progression.
Creative Biolabs offers CCR9 downstream pathways research services. CCR9 can activate various downstream pathways, such as the β-catenin pathway, which contributes to chemotherapy resistance in pancreatic cancer. Targeting these downstream pathways can enhance the effectiveness of cancer treatments.
Creative Biolabs offers comprehensive and innovative services to drive the development of CCR9 cell therapy. Please inquire with us for more services.
Creative Biolabs offers optimization of CAR design services. Various strategies can be employed to optimize the design of CAR-T cells targeting CCR9. For example, transient transfection of T cells with CAR-encoding mRNA can limit the expression of CARs and reduce lethal cytotoxicity.
Creative Biolabs offers in vitro assay services. CAR-T cells targeting CCR9 can be tested against CCR9+ cancer cell lines to evaluate their cytotoxicity, cytokine secretion, and proliferation capabilities. For example, CARCCR9 cells demonstrated cytotoxicity, cytokine secretion, and proliferation against CCR9+ T-ALL cell lines, even at low target density.
With years of experience and advanced technology, Creative Biolabs offers expert support for membrane protein studies with best-in-class membrane protein preparation strategies and procedures. Our scientific team offers not only regular membrane protein preparation services but also customized services based on the requirements of our clients, with a great value service with exceptional quality and rapid reporting. Please feel free to for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
