Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | C-X-C motif chemokine receptor 4 |
| Gene Name | CXCR4 |
| Uniprot | P61073 (Human); P70658 (Mouse) |
| Synonym | FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; WHIMS; HSY3RR; NPYY3R; D2S201E; C-X-C chemokine receptor type 4; CD184 antigen; LPS-associated protein 3; SDF-1 receptor; chemokine (C-X-C motif) receptor 4; fusin; leukocyte-derived seven transmembrane domain receptor; lipopolysaccharide-associated protein 3; neuropeptide Y receptor Y3; neuropeptide Y3 receptor; seven transmembrane helix receptor; seven-transmembrane-segment receptor, spleen; stromal cell-derived factor 1 receptor |
| Background | CXCR4 is a G protein-coupled receptor in the CXC chemokine receptor family, encoded by CXCR4 gene. It is one of seven CXC chemokine receptors (CXCR1-CXCR7) in mammals. The receptors can recognize CXC chemokine that possesses an E-L-R amino acid motif. CXCR4 is widely expressed in many human tissues, such as lymph node, bone marrow. Recently, most studies focus on the role of CXCR4 in the pathological process of cancer. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX447 | NativeExtract™ Human CXCR4 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPVLP-014 | MemDX™ Recombinant Human CXCR4 Membrane Protein in Virus-Like Particles (MP-VLPs) | HEK293 cells | Full length | VLPs |
| MPVLP-015 | MemDX™ Recombinant Mouse CXCR4 Membrane Protein in Virus-Like Particles (MP-VLPs) | HEK293 cells | Full length | VLPs |
| MP1346J | MemDX™ Membrane Protein Human CXCR4 (C-X-C motif chemokine receptor 4) for Antibody Discovery | E.coli cell-free | Full length | Detergent |
| MP0280X | MemDX™ Membrane Protein Human CXCR4 (C-X-C motif chemokine receptor 4) with GST-tag for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| MP0279X | MemDX™ Membrane Protein Human CXCR4 (C-X-C motif chemokine receptor 4) without tag for Antibody Discovery | Wheat germ cell-free | Full length | Liposome |
| Please for more products or customization | ||||
M***n: My experience with Creative Biolabs and their protein has been outstanding.
12/Mar/2023
A***ia: I highly recommend Creative Biolabs to anyone in need of high-quality CXCR4 protein or other related products. They are a reliable and trustworthy supplier that I will definitely continue to work with in the future.
07/Mar/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
CXCR4-Targeted Polymer Nanoparticles
Creative Biolabs offers CXCR4-targeted polymer nanoparticles development services. The strategic engineering of various polymeric materials has become a cornerstone in the development of sophisticated nanocarrier systems for precise drug delivery. Among these, poly(lactic-co-glycolic acid) (PLGA) has emerged as a particularly versatile and widely adopted platform due to its biocompatibility and tunable degradation kinetics. A compelling illustration of this technological paradigm involves the surface functionalization of doxorubicin-encapsulating PLGA nanoparticles with a CXCR4 antagonist. This deliberate molecular adornment, consequently, facilitates the targeted delivery of the cytotoxic payload to specific cellular populations, notably in both breast and lung adenocarcinoma lineages. This precision targeting, perhaps mitigating off-target toxicities while concentrating therapeutic agents at the disease site, represents a significant stride towards optimizing oncological pharmacotherapy.
Targeted Mutations
Creative Biolabs offers targeted mutations services. Investigations have increasingly pointed towards a nuanced genetic engineering strategy involving the deliberate introduction of targeted mutations within the CXCR4 gene. This meticulous approach aims to effect specific amino acid substitutions, which, critically, are designed to perturb the receptor's intrinsic functional activity without necessitating a complete genetic ablation, or "knockout." The rationale underpinning this refined methodology is rooted in the imperative to minimize the potentially severe physiological sequelae widely associated with a comprehensive loss of CXCR4 expression. Indeed, complete knockout of this gene has been observed to induce profound developmental and systemic abnormalities, a challenge that this targeted mutational strategy, perhaps offering a more refined molecular intervention, endeavors to circumvent.
Creative Biolabs offers comprehensive and innovative services to drive the development of CXCR4 cell therapy. Please for more services.
Cell Surface Patching via CXCR4-Targeted Nanothreads
Creative Biolabs offers cell surface patching via CXCR4-targeted nanothreads development services. A burgeoning methodological paradigm in oncology centers on the deployment of CXCR4-targeted nanothreads, engineered to exert a profound influence on the spatial organization of cell-surface CXCR4. This innovative approach aims to actively perturb the intricate dynamic equilibrium maintained between CXCR4 monomers, dimers, and higher-order multimers on the cellular membrane. By strategically altering this fundamental receptor assembly, the overarching objective is to effectively thwart metastatic progression through a comprehensive disruption of the entire CXCR4 signaling network. This intricate mechanism, perhaps operating via allosteric regulation, holds substantial promise for inhibiting cellular processes critical for metastasis. The nanothreads, therefore, might precisely modulate downstream signaling cascades, offering a novel avenue for therapeutic intervention against tumor dissemination.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
