Chemokines are a family of chemoattractant molecules which attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. They exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. C-X-C chemokine receptors are a large subfamily of G protein-coupled receptors that specifically bind and respond to cytokines of the CXC chemokine family. They are preferentially expressed on important functional subsets of dendritic cells, monocytes, and lymphocytes, including Langerhans cells and T helper cells. Currently, there are six known CXC chemokine receptors in mammals, named CXCR1 through CXCR6. Studies have shown that they act important roles in both normal and pathological processes including allergic responses, infectious and autoimmune disease, angiogenesis, inflammation, and tumor growth and metastasis.
Here, we give a comprehensive introduction for the members of C-X-C chemokine receptor family, such as C-X-C chemokine receptor type 1, C-X-C chemokine receptor type 2, and C-X-C chemokine receptor type 3. To learn more information, please click the links below.
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