| Protein Name | Dopamine receptor D5 |
| Gene Name | DRD5 |
| Uniprot | P21918 (Human); Q8BLD9 (Mouse) |
| Synonym | DBDR; DRD1B; DRD1L2; D(1B) dopamine receptor; D1beta dopamine receptor; d(5) dopamine receptor; dopamine D5 receptor; dopamine receptor D1B |
| Background | DRD5 also referred as DBDR, is the D5 subtype of the dopamine receptor that in humans is encoded by the DRD5 gene. Highly homologous to the D1 receptor, DRD5 belongs to the D1-like receptor family together with the D1 receptor subtype. Via activating adenylyl cyclase, the activity of DRD5 is mediated by G proteins. This protein found in the brain functions together with a chemical messenger (neurotransmitter) termed dopamine. Dopamine triggers chemical reactions within nerve cells through perfectly fits into the D5 receptor. Dopamine signaling plays a critical role in the brain, such as the regulation of attention, mood, memory, learning, and movement. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX280 | NativeExtract™ Human DRD5 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPX3605K | MemDX™ Membrane Protein Human DRD5 Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| MP0309X | MemDX™ Membrane Protein Human DRD5 (Dopamine receptor D5) for Antibody Discovery | Wheat germ cell-free | Full length | Liposome |
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Gene Editing
Creative Biolabs offers gene editing services. The application of genome-editing technologies enables precise modification of DRD5 loci within neoplastic cells, providing a powerful experimental paradigm for elucidating this receptor's tumor-suppressive functions. Such targeted genetic perturbations may reveal novel molecular vulnerabilities that could be exploited for therapeutic intervention in malignancies where DRD5 signaling is compromised.
Lentiviral Vectors for Overexpression
Creative Biolabs offers lentiviral vectors development services. Lentiviral vector-mediated gene transfer enables robust overexpression of the DRD5 in cellular systems exhibiting deficient endogenous expression. This genetic augmentation strategy may potentiate the tumor-suppressive effects of DRD5 signaling, potentially offering a novel approach for targeted oncological interventions.
Creative Biolabs offers comprehensive and innovative services to drive the development of DRD5 cell therapy. Please for more services.
Primary Cell Cultures
Creative Biolabs offers primary cell cultures services. Primary tumor-derived cell cultures serve as valuable experimental platforms for assessing the therapeutic potential of DRD5-targeted compounds. These ex vivo models facilitate comprehensive evaluation of pharmacological interventions, enabling quantitative analysis of treatment effects on critical cellular processes including viability, proliferative capacity, and programmed cell death pathways.
Animal Models
Creative Biolabs offers animal models development services. The development of transgenic animal models expressing human DRD5 receptors offers a powerful approach to investigate the physiological consequences of receptor activation in tumorigenesis. Such models not only enable systematic analysis of DRD5-mediated effects on neoplastic growth and metastatic progression but also provide a robust preclinical platform for evaluating the therapeutic index of novel DRD5-targeted compounds.
Stem Cell Delivery Systems
Creative Biolabs offers stem cell delivery systems development services. Engineered stem cells represent a promising delivery platform for DRD5-targeted interventions, capable of either expressing the receptor itself or transporting therapeutic payloads to malignant tissues. This targeted strategy may substantially improve treatment precision and therapeutic outcomes while potentially minimizing off-target effects associated with systemic drug administration.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.