Dopamine receptors (DR), including D1-5 (also called DRD1-5), are originally identified to be the receptors for dopamine, an endogenous neurotransmitter that controls a variety of brain functions, including emotion, cognition, and movement. Furthermore, dopamine also plays a significant role in human placental endocrine function, and it has the ability to inhibit human placental lactogen (hPL) and human chorionic gonadotrophin production. As a G protein-coupled receptor member, DR is classified into D1-like (including DRD1 and DRD5) and D2-like (including DRD2, DRD3, and DRD4) families according to their coupled G proteins, Gαs or Gαi. It has been reported that dopamine receptors, particularly the D2-like receptors, have been implicated in the pathophysiology of many neurogenic diseases such as Parkinson and Alzheimer. And relevant agonists or antagonists have been used to target DR for therapy or modified to generate effective probes for live imaging.
Here, we give a comprehensive introduction for members of the DR family, including but not limited to dopamine D1 receptor, dopamine D2 receptor, and dopamine D3 receptor. To learn more detailed information, please click the links below.
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