IVD Antibody Development Services for α Subunit of G_s Marker

Having worked in the field of in vitro diagnostics (IVDs) market for many years, Creative Biolabs has established a universal platform for IVD antibody discovery and development. Especially, we provide IVD antibody development services against α subunit of G_s marker of bladder cancer.

Introduction of the α Subunit of G_s Marker

The α subunit of G_s protein (G_sα) is a heterotrimeric G protein subunit that is encoded by GNAS gene located on the telomeric end of the long arm of chromosome 20. As one of the three main families of G proteins, it is ubiquitously expressed in many cell types and responsible for the receptor-stimulated cAMP generation and activation of protein kinase A (PKA) pathway. Moreover, the α subunit of the heterotrimeric stimulatory G protein (G_αs) is essential for the cellular actions of many hormones, neurotransmitters, and autocrine/paracrine factors.

Fig.1 Classification of G proteins into four families according to their α subunit. (Kamato D., 2015)

α Subunit of G_s Marker of Bladder Cancer

In the past years, tumor progression is thought to result from the accumulation of multiple genetic alterations, including the activation of oncogenes, loss of distinct chromosomal regions, and inactivation of tumor suppressor genes. However, recent investigations have shown that an increased concentration of the intracellular second messenger cyclic AMP (cAMP) promotes apoptosis in several cell types, including leukemic cells, ovarian cancer cells, bladder cancer cells, and lymphoma cells. Most importantly, elevation of cAMP results from signal transduction from G protein-coupled receptors to the G_αs protein, which in turn activates its effector adenylyl cyclase to produce cAMP. Under this condition, G_αs protein can be used as a novel prognostic marker for bladder cancer.

Fig.2 Activation of G_s and stimulation of adenylyl cyclase by the EGF receptor. (Patel T B., 2004)

IVD Antibody Development Services Targeting α Subunit of G_s

IVD antibodies have been widely used in the diagnosis of different diseases, including cancers. What's more, antibody-based immunoassays are the most generally used in vitro diagnostic assays for the detection of analytes. With our versatile IVD platform, Creative Biolabs is proud to develop novel biomarker-specific (paired) antibodies from scratch to commercial IVD kit (we can also start with provided antibody candidates). Our high-affinity IVD antibodies have greatly promoted our client's programs development.

In addition to α subunit of G_s marker, Creative Biolabs also provides IVD antibody development services targeting other potential markers of bladder cancer. Our experienced scientists will work hard to ensure our client's project a success. To get more detailed information, please feel free to contact us and get a quote.

References

1. Kamato D, et al. (2015). “Structure, function, pharmacology, and therapeutic potential of the G protein, Gα/q, 11.” Frontiers in cardiovascular medicine, 2: 14.
2. Patel T B. (2004). “Single transmembrane spanning heterotrimeric g protein-coupled receptors and their signaling cascades.” Pharmacological reviews, 56(3): 371-385.

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