Creative Biolabs is a well-recognized expert in the field of antibody generation and production. Especially, we have launched a series of in vitro diagnostic (IVD) antibody development services for different infections and diseases. Scientific progress has resulted in the discovery of novel disease biomarkers to fulfill the need for a quicker, more specific and more accurate diagnosis. Particularly, we provide IVD antibody development services against the TIMP-1 marker.

Introduction of TIMP-1

Tissue inhibitor of metalloproteinases 1 (TIMP-1, TIMP) is a glycosylated protein widely synthesized by many cells and tissues. TIMP-1 is a natural inhibitor of the matrix metalloproteinases (MMPs), as well as the closely related, a disintegrin and metalloproteinases (ADAMs) and ADAMs with thrombospondin motifs (ADAMTSs). MMPs are a group of peptidases involved in degradation of the extracellular matrix. TIMPs are thought to control extracellular matrix (ECM) proteolysis through direct inhibition of MMP-dependent ECM proteolysis. Therefore, increased TIMP levels may result in ECM accumulation (or fibrosis), whereas loss of TIMPs may lead to enhanced matrix proteolysis. Besides its inhibitory role against MMPs, TIMPs can promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. An improper balance of MMP and TIMP production correlates with pathological conditions such as arthritis, tumor growth and metastasis.

Summary of the processes mediating recovery from liver fibrosis and the mechanisms regulating HSC survival and apoptosis. Fig.1 Effects of TIMP1 on apoptosis and its related pathway. (Song, G., 2016)

TIMP-1 Marker for Liver Fibrosis

Hepatic fibrosis is a pathological process with the net deposition of ECM proteins. Both in murine experimental models and human samples, TIMP-1 has been shown to be upregulated during hepatic fibrogenesis and considered to promote fibrosis in the injured liver by inhibition of MMPs and degradation of ECM. Murawaki et al. have revealed that the serum level of TIMP-1 can reflect the change of liver TIMP-1 in patients with chronic liver disease, such as liver fibrosis. In addition, in patients with hepatocellular carcinoma (HCC), TIMP-1 displays anti-apoptotic properties and its serum levels are elevated, which is associated with a poor prognosis. Therefore, TIMP-1 can be regarded as an effective biomarker reflecting the severity of fibrogenesis and fibrinolysis, providing a useful tool for evaluating liver fibrosis.

Effects of TIMP1 on apoptosis and its related pathway. Fig.2 Summary of the processes mediating recovery from liver fibrosis and the mechanisms regulating HSC survival and apoptosis. (Henderson, N. C., 2007)

IVD Antibody Development Services for TIMP-1 Marker

TIMP-1 plays a vital role in carcinogenesis, suggesting its great potential for the diagnosis and prognosis of diversified diseases. Detection of serum TIMP-1 may benefit the detection of liver fibrosis at an early stage. Therefore, it is important to explore IVD antibodies against TIMP-1, which can be used in diagnostic immunoassays for the diagnosis and prognosis of liver diseases and colon cancer.

Equipped with advanced platforms and experienced scientists, Creative Biolabs has won a good reputation in the field of IVD antibody development. We are confident in the production, purification, and characterization of IVD antibodies against specific biomarkers of different diseases. We will be your best partner to provide premade and customized IVD antibody services to promote your brilliant projects. Please contact us for more information.

References

  1. Song, G., (2016). “TIMP1 is a prognostic marker for the progression and metastasis of colon cancer through FAK-PI3K/AKT and MAPK pathway.” Journal of Experimental & Clinical Cancer Research, 35(1), 148.
  2. Henderson, N. C., (2007). “Liver fibrosis: cellular mechanisms of progression and resolution.” Clinical Science, 112(5), 265-280.


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