As a world-leading service provider of antibody development and generation, Creative Biolabs is ready to provide a whole series of biomarker-specific in vitro diagnostic (IVD) antibody development services. Here,we introduce our IVD antibody development services for Varicella zoster virus (VZV). A team of experienced scientists focused on antibody development are pleased to assist you in your project in a timely and cost-effective manner.

Introduction of VZV

Varicella zoster virus (VZV), which is a highly neurotropic member of the herpesvirus family, causes varicella (also known as chickenpox) and zoster (also known as shingles). VZV is a worldwide pathogen that can be transmitted by respiratory droplets and by direct personal contact with vesicular fluid. VZV infections are species-specific to humans, but can survive in external environments for a few hours, maybe a day or two. Epidemiological evidence suggests that primary VZV infection begins with replication in epithelial cells of the upper respiratory mucosa, which is followed by the widely distributed vesicular rash that is typical of varicella after an incubation period of 10–21 days. What’s more, the disease is infectious 48 hours before the rash appears and continues to be infectious until the vesicles crust over.

VZV life cycle and replicationFig.1 VZV life cycle and replication (Zerboni L.,2014)

Correlation of VZV and Childhood

VZV usually affects children under ten years and recovery occurs spontaneously. Around 90% of adults will have had varicella and as a result developed immunity to VZV. However, studies have suggested that people having varicella more than once either because the individual has not produced sufficient antibodies for immunity to be established after the initial infection or because more than one strain of the virus exists. Importantly, children usually develop infection between March and May, but it can occur at any time of the year. What’s more, varicella is not usually serious in healthy children, who generally recover spontaneously without complications. When adults develop varicella, they usually feel iller than children and are more likely to develop complications.

IVD Antibody Development Service for VZV

In recent years, IVD technologies are undergoing rapid development. IVD antibodies have been widely used for the detection of numerous diseases, conditions, and infections. Through our role as a leading antibody service provider, Creative Biolabs is well-positioned to develop high-quality anti-VZV antibodies. Besides antibody generation, Creative Biolabs also offers diagnostic immunoassay development services, including feasibility analysis, assay design, assay protocol establishment, assay optimization, and kit production.

Creative Biolabs has successfully completed a number of IVD antibody generation and development projects for clients across the globe. For more details and information, please feel free to contact us or directly send us an inquiry.

Reference

  1. Zerboni L., (2014) “Molecular mechanisms of varicella zoster virus pathogenesis.” Nature reviews microbiology, 12(3): 197.

For Research Use Only.



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