As a well-established company in the bio-industry, Creative Biolabs offers a full range of in vitro diagnostics (IVD) services. Guaranteed to perform within the specified time frame, and the quality of various disease research is always maintained to the end. Our laboratory services have many advanced microsphere-based nucleic acid assays, such as microsphere-based single nucleotide polymorphism (SNP) assays, to support customer's needs in the fast-growing disease diagnosis projects.
In the past few years of studies, the identification of biomarkers or serotypes for many infectious diseases has become the cornerstone of our understanding of disease epidemiology. Meanwhile, the epitope mapping of different antigens also plays an important role in immunogenicity evaluation. As a result, a wide variety of microsphere-based liquid arrays have been generated for determining different antigen types and representing antigen epitopes.
Moreover, microsphere-based liquid arrays have been broadly used in genomic research, such as SNP genotyping, gene expression profiling, disease biomarker identification, as well as early drug screening. In general, a wide variety of microsphere beads (approximately 4-6μm in diameter) are used to prepare arrays. Each type of microsphere bead is labeled differently according to its unique optical characteristics, such as fluorescence. Depending on the color and unique wavelength of each fluorescence tag, multiple gene mutations can be detected simultaneously. Besides, the microspheres are easily suspended in the liquid array and exhibit favorable dynamics during the detection process.
Fig.1 Schematic illustration of the sensing principle of the polystyrene (PS) beads-based suspension array for simultaneous measurement of multiple miRNAs. (Wang, 2020)
Currently, in vitro disease diagnosis is one of the long-term challenges in the biomedical industry. To solve the difficulties of traditional IVD approaches, microsphere-based nucleic acid assays have been regarded as effective strategies for determining DNA markers in various disease types.
With the commitment of being your best drug discovery partner, Creative Biolabs has established a panel of microsphere-based nucleic acid assays for our clients to screen, sequence, and/or quantitate a nucleic acid of interest. The data derived from our studies have indicated that our assays are a series of rapid, accurate, high-throughput, and large-scale testing methods for analyzing nucleic acid samples. For instance, a battery of nucleic acid assays has been designed for incubating fluorescent tags cDNA or DNA oligonucleotide probes to specifically labeled microspheres. The abundance of each target in different samples can be further determined by collecting and analyzing different fluorescent signals.
Fig.2 Fluorescence emission intensity (at 520 nm) of the PS-bead sensor unit. (Wang, 2020)
Nowadays, Creative Biolabs has established the utmost efficient integrated microsphere-based nucleic acid assays solutions to innovate and accelerate your disease diagnosis and treatment. Our platform is equipped with state-of-the-art facilities and highly experienced staff is available to assist in all areas of nucleic acid studies. We have integrated high-quality services that are based in America and span the entire development chain all over the world.
Creative Biolabs is a leading drug development company, providing a wide spectrum of microsphere-based nucleic acid assays from disease diagnosis. With our one-stop IVD solution platform, we are ready to help you tackle your toughest research challenge. If you are interested in our services, please contact us for closer communication to learn how we can be involved in your project. Separate services or integrated end-to-end solutions are all welcomed.
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