Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Endothelin receptor type B |
| Gene Name | EDNRB |
| Uniprot | P24530 (Human); P48302 (Mouse) |
| Synonym | ETB; ET-B; ETB1; ETBR; ETRB; HSCR; WS4A; ABCDS; ET-BR; HSCR2; Hirschsprung disease 2; endothelin receptor non-selective type; endothelin receptor subtype B1 |
| Background | EDNRB, termed ETB, is a member of the endothelin receptor group of G-protein-coupled receptors that also containing ETA. These receptors, primarily present in vascular endothelial cells, play a role in vasoconstriction, vasodilation and cell proliferation. Its ligand, endothelin, a 21-amino-acid peptide, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. EDNRB activates a phosphatidylinositol-calcium second messenger system. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX278 | NativeExtract™ Human EDNRB Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| S01YF-0622-KX159 | MemDX™ Recombinant Human EDNRB Membrane Protein in Virus-Like Particles (MP-VLPs) | HEK293 cells | Full length | VLPs |
| MPX4697K | MemDX™ Membrane Protein Human EDNRB Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| MP1042J | MemDX™ Membrane Protein Human EDNRB (Endothelin receptor type B) for Antibody Discovery | HEK293 cells | Full length | N/A |
| MP0320X | MemDX™ Membrane Protein Human EDNRB (Endothelin receptor type A) with GST-tag for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| MP0319X | MemDX™ Membrane Protein Human EDNRB (Endothelin receptor type A) without tag for Antibody Discovery | Wheat germ cell-free | Full length | Liposome |
| Please contact us for more products or customization | ||||
Z**a: I had a great experience purchasing the EDNRB protein from Creative Biolabs.
13/Aug/2023
L**r: I appreciate the attention to detail and the commitment to customer satisfaction that Creative Biolabs demonstrates.
22/Mar/2024
We provide tailored solutions to meet your specific requirements. Please inquire us for more services.
Viral Vector-Mediated Gene Transfer
Creative Biolabs offers viral vector-mediated gene transfer services. Gene delivery systems employing recombinant adenoviral or lentiviral vectors can effectively introduce a functional EDNRB transgene into target cells, enabling precise genetic modulation. In vitro studies have demonstrated the utility of this approach; for example, recombinant adenovirus-mediated EDNRB transduction has been successfully applied in oral squamous cell carcinoma (OSCC) models to investigate its influence on proliferative capacity and cellular viability. These findings suggest that such a strategy may be adaptable for therapeutic intervention, particularly in pathologies characterized by deficient EDNRB expression.
Non-Viral Gene Delivery
Creative Biolabs offers non-viral gene delivery services. Non-viral gene delivery methods, including electroporation and lipid-mediated transfection, provide a viable alternative for introducing EDNRB-encoding plasmids into target cells. Unlike viral vector systems, these approaches circumvent the risk of immunogenic responses, a consideration of critical importance in therapeutic applications. Preclinical investigations have extensively explored such strategies, demonstrating their feasibility for modulating gene expression without eliciting adverse immune reactions.
DNA Methylation Inhibition
Creative Biolabs offers DNA methylation inhibition services. Emerging evidence indicates that hypermethylation of the EDNRB promoter region occurs in specific pathological states, resulting in transcriptional silencing of this critical gene. This epigenetic dysregulation, observed across multiple disease contexts, correlates strongly with diminished EDNRB expression levels. Such epigenetic reprogramming strategies may offer a targeted therapeutic avenue for conditions characterized by EDNRB suppression.
Creative Biolabs offers comprehensive and innovative services to drive the development of EDNRB cell therapy. Please inquire with us for more services.
Murine Models
Creative Biolabs offers murine model development services. In the field of regenerative medicine, the capacity of enteric neural crest cells (ENCCs) to differentiate and integrate into existing neural structures has garnered significant attention. Groundbreaking studies involving the orthotopic transplantation of ENCCs into both wild-type and Hirschsprung's disease (HSCR) murine models have provided compelling evidence of their developmental plasticity. These investigations unequivocally demonstrated the intrinsic ability of these progenitor cells to effectively engender and subsequently colonize both neuronal and glial cell lineages, culminating in the de novo formation of intricate enteric nervous system (ENS)-like networks.
iPSCs Generation and Differentiation
Creative Biolabs offers iPSC generation and differentiation services. In the dynamic landscape of regenerative medicine, the generation of induced pluripotent stem cells (iPSCs) from patient-specific somatic cells, particularly fibroblasts, represents a pivotal advancement. These iPSCs possess the remarkable capacity for directed differentiation into a myriad of cell types, including the highly specialized enteric neural crest cells (ENCCs). A significant advantage of this methodology lies in its potential to correct any underlying mutations within these patient-derived cells. Following such meticulous genetic amelioration, these re-engineered ENCCs can then be proposed for subsequent transplantation. This innovative therapeutic paradigm offers a compelling pathway for the development of patient-specific cellular therapies.
As a forward-looking research institute as well as a leading custom service provider in the field of membrane protein, Creative Biolabs has won good reputation among our worldwide customers for successfully accomplishing numerous challenging projects, including the generation of many functional membrane proteins. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
