Introduction of EDNRB
EDNRB, termed ETB, is a member of the endothelin receptor group of G-protein-coupled receptors that also containing ETA. These receptors, primarily present in vascular endothelial cells, play a role in vasoconstriction, vasodilation and cell proliferation. Its ligand, endothelin, a 21-amino-acid peptide, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. EDNRB activates a phosphatidylinositol-calcium second messenger system.
|Basic Information of EDNRB|
|Protein Name||Endothelin receptor type B|
|Organism||Homo sapiens (Human)|
Function of EDNRB Membrane Protein
EDNRB, together with endothelin, are involved in the development of various diseases, including pulmonary arterial hypertension, and thus are important therapeutic targets. Studies suggest that mutations in the endothelin receptor type B gene contribute the multigenic disorder, Hirschsprung disease type 2. Endothelin-1 induces activation of the downstream MAP kinases (mainly) ERK1/2 by EDNRB but the exact mechanism is unclear. EDNRB is targeted to caveolae by binding to Caveolin-1. Research has shown that EDNRB dissociates from Caveolin-1 and exits from the caveolae after stimulation of endothelin-1. Caveolae localization of EDNRB is one of the mechanisms to ensure the balance of EDNRB -mediated signal transduction.
Application of EDNRB Membrane Protein in Literature
This article shows that crystal structures of human endothelin type B receptor and in complex with the endogenous agonist endothelin-1.
This article suggests that the combination of ET(A)R antagonist with ET(B)R agonist may need to be evaluated in conditions associated with decreased endothelial ET(B)R expression/activity.
This article reveals that endothelin-1 receptor type B plays a role in IH-induced impairments in glucose homeostasis.
This article indicates that altered ETBR is involved in diminished endothelium-dependent dilation in women patients with previously preeclamptic.
This article reveals that in the diabetic kidney increased ETB-R signaling improves intrarenal tissue oxygenation due to increased oxygen delivery secondary to increased renal blood flow.
EDNRB Preparation Options
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