Introduction of GABRA1
Gamma-aminobutyric acid receptor subunit alpha-1 (GABRA1), also known as GABA(A) receptor subunit alpha-1, is a protein encoded by the human GABRA1 gene. It is a member of the type A γ-aminobutyric acid (GABAA) receptors which represent a large and diverse family of ligand-gated CI-channels that mediate the majority of fast inhibitory neurotransmission in the brain. As the specific target of the z-drug class of nonbenzodiazepine hypnotic agents, GABRA1 is responsible for their hypnotic and hallucinogenic effects.
|Basic Information of GABRA1|
|Protein Name||Gamma-aminobutyric acid receptor subunit alpha-1|
|Aliases||GABA(A) receptor subunit alpha-1|
|Organism||Homo sapiens (Human)|
Function of GABRA1 Membrane Protein
Gamma-aminobutyric acid (GABA)A receptors are characterized by extreme heterogeneity resulting from a large number of subunits forming this receptor. So far, as many as at least 20 subunits (α1−6, β1−3, γ1−3, δ, ε, θ, π, and ρ1−3) of this receptor have been cloned, which determine the receptor's agonist affinity, chance of opening, conductance, and other properties. As a member of the GABAA receptors family, the GABRA1 receptor is the specific target of the z-drug class of nonbenzodiazepine hypnotic agents and is responsible for their hypnotic and hallucinogenic effects. Studies have shown that GABAA receptors are widely distributed in all organisms that have a nervous system, which indicates that they play a role in virtually all brain functions. What’s more, it has been reported that GABRA1 is associated with hereditary generalized epilepsies, like juvenile myoclonic epilepsy, as well as sporadic epileptic encephalopathies, such as Dravet and Ohtahara syndromes.
Fig.1 Schematic structure of the GABAA receptor.
Application GABRA1 of Membrane Protein in Literature
This article suggests that the NAc core plays a role in the pathogenesis of schizophrenia and GABAAR α1 may be a potential pharmacological target for its treatment.
This article shows how chronic ethanol exposure regulates the highly prominent GABAAR α1 subunit by an epigenetic mechanism, which represents a potential treatment modality for alcohol dependence.
This report suggests that GABRA1 mutations are associated with early infantile epileptic encephalopathy type 19 (EIEE19) and GABRA1 p.Met263Ile is associated with a distinct West syndrome phenotype.
This article aims to investigate the clinical features of a cohort of patients with GABRA1 gene mutations. It suggests that GABRA1 mutations make a significant contribution to the genetic etiology of both benign and severe epilepsy syndromes.
This article aims to evaluate the association between genetic variants on drug response and therapy optimization parameters in patients treated with first-line antiepileptic drugs (AEDs). The results suggest that GABRA1 plays a role in phenytoin mode of action.
GABRA1 Preparation Options
To satisfy every client’s specific requirements, we have developed an advanced Magic™ membrane protein production platform which enables us to provide a series of membrane protein products for worldwide customers. Besides, aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-GABRA1 antibody development services.
Aided by extensive experience and professional scientists, Creative Biolabs is confident in offering membrane protein preparation services in the most high-quality and cost-effective way. In addition to GABRA1 membrane protein preparation services, we also provide other membrane protein preparation services to meet every client’s specific requirements. To learn more detailed information, please feel free to contact us for more information.