Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe GABA receptors are a class of transmembrane proteins that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the mature vertebrate central nervous system. GABA receptors mediate neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. There are two classes of GABA receptors that have been identified: GABA(A) and GABA(B). GABA(A) receptors are ligand-gated ion channels (also called the ionotropic receptors), while GABAB receptors are G protein-coupled receptors, which are also known as metabotropic receptors. An increase in the GABA receptor concentration leads to an increase in the mean channel open time due to the opening of doubly liganded receptor forms, which exhibit open states of long duration.
Since GABA receptors are widely distributed and utilized throughout the CNS (central nervous system), early GABA-ergic target drugs have a quite extensive effect on CNS function. And thus, they are considered to be attractive drug targets. Below shows part of the GABA receptor family members, on which we have given further information for your review.
| Human GABA Receptor Family Members | ||||
| GABRA1 | GABRA2 | GABRA3 | GABRA4 | GABRA5 |
| GABRA6 | GABRB1 | GABRB2 | GABRB3 | GABRD |
| GABRE | GABRG1 | GABRG2 | GABRG3 | GABRGP |
| GABRR1 | GABRR2 | GABRR3 | ||
Utilizing our efficient Magic™ membrane protein production platform, Creative Biolabs is able to offer the preparation of these two membrane proteins in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
In addition, our Magic™ membrane protein antibody discovery platform can be applied in developing antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more details.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
