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HighlightsIntroduction of GABRP
Gamma-aminobutyric acid receptor subunit pi (GABRP), also known as GABA(A) receptor subunit pi, is a protein that in humans is encoded by the GABRP gene. The amino acid sequence of the pi subunit is most closely related to GABAA receptor β- and δ-subunits, and is less similar to other GABAA receptor or glycine receptor subunits.
| Basic Information of GABRP | |
| Protein Name | Gamma-aminobutyric acid receptor subunit pi |
| Gene Name | GABRP |
| Aliases | GABA(B) receptor subunit pi |
| Organism | Homo sapiens (Human) |
| UniProt ID | O00591 |
| Transmembrane Times | 4 |
| Length (aa) | 440 |
| Sequence | MNYSLHLAFVCLSLFTERMCIQGSQFNVEVGRSDKLSLPGFENLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEGNKSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTRSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAKDRGTTKEVEEVSITNIINSSISSFKRKISFASIEISSDNVDYSDLTMKTSDKFKFVFREKMGRIVDYFTIQNPSNVDHYSKLLFPLIFMLANVFYWAYYMYF |
Function of GABRP Membrane Protein
The pi-subunit of the g-aminobutyric acid (GABA) receptor, encoded by the gene GABRP, is a transmembrane protein that belongs to the GABA(A) receptors family. The polypeptide of GABRP has all of the hallmarks of a ligand-gated anion channel subunit. However, unlike other GABA(A) subunits, GABRP is not abundant in the brain but is detectable in multiple non-neuronal normal human tissues, including the mammary gland, prostate gland, lung, thymus, and uterus. It has been reported that GABRP is also highly expressed in certain types of cancer such as pancreatic ductal adenocarcinoma and basal-like breast cancer. Furthermore, there is progressive downregulation in concordance with tumor progression in sporadic breast cancer tissues. And, expression of GABRP is also associated with the basal-like/triple negative subtype, brain metastases, and poorer prognosis.
Fig.1 Schematic representation of GABAAR and the GABAergic synapse. (Farb, 2014)
Application GABRP of Membrane Protein in Literature
This article suggests that GABRP could enhance the aggressive phenotype of ovarian cancer cells, and the DNA methylation status of the GABRP-963 CpG site may be useful for predicting the metastatic potential in ovarian cancer patients.
This article aims to validate whether the polymorphisms in the GABRP gene are associated with the susceptibility to systematic lupus erythematosus (SLE). It suggests that the polymorphisms in the GABRP gene might be associated with the susceptibility to SLE and the haplotype of GABRP SNPs is a useful genetic marker for SLE.
This article suggests that a GABRP-ERK1/2-cytokeratin axis that maintains the migratory phenotype of basal-like breast cancer. GABRP is a component of a cell surface receptor, thus, these findings indicate that targeting this new signaling axis may have therapeutic potential in basal-like breast cancer.
This article suggests that GABRP is progressively down-regulated with tumor-progression and that it may be useful as a prognostic marker in breast cancer.
GABRP Preparation Options
To provide numerous membrane protein products, we have developed an advanced Magic™ membrane protein production platform which enables many options, from which we will find you the perfect one. Besides, aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-GABRP antibody development services.
Based on years of experience and professional scientists, Creative Biolabs has successfully provided a series of high-quality membrane protein preparation services for worldwide clients. Except for GABRP membrane protein products, we also provide other membrane protein preparation services to meet every client’s specific requirements. To learn more information, please feel free to contact us for more information.
Reference
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