GABRR2 Membrane Protein Introduction

Introduction of GABRR2

The Gamma-aminobutyric acid receptor subunit rho-2(GABRR2), which in humans is encoded by the GABRR2 gene, is also known as a GABA-ρ receptor. GABRR2 is a member of the rho subunit family. GABA receptors are ligand-gated chloride channels, where GABA acts at. GABA is a major inhibitory neurotransmitter in the mammalian brain. GABA(A) receptor subunit rho-2(GABRR2) could play an important role in retinal neurotransmission.

Basic Information of GABRR2
Protein Name	Gamma-aminobutyric acid receptor subunit rho-2
Gene Name	GABRR2
Aliases	GABA(A) receptor subunit rho-2, GABA(C) receptor
Organism	Homo sapiens (Human)
UniProt ID	P28476
Transmembrane Times	4
Length (aa)	465
Sequence	MPYFTRLILFLFCLMVLVESRKPKRKRWTGQVEMPKPSHLYKKNLDVTKIRKGKPQQLLRVDEHDFSMRPAFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLAFSSASNKSMTFDGRLVKKIWVPDVFFVHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNMDFSHFPLDSQTCSLELESYAYTDEDLMLYWKNGDESLKTDEKISLSQFLIQKFHTTSRLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVSLGITTVLTMTTIITGVNASMPRVSYVKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKERKLREKFPCMCGMLHSKTMMLDGSYSESEANSLAGYPRSHILTEEERQDKIVVHLGLSGEANAARKKGLLKGQTGFRIFQNTHAIDKYSRLIFPASYIFFNLIYWSVFS

Function of GABRR2 Membrane Protein

GABA(C) receptors are bicuculline- and baclofen-insensitive ionotropic GABA receptors which are formed by subunits. GABA(C) receptors may simply be a subset of GABA(A) channels. GABRR2 are located in certain areas of the central nervous system and in the retinas in humans. They form Cl^- channels, assumed to organize in either homo- or heteromers of the humans. Outside of the central nervous system and retina, the expression of GABA(C) receptor subunits has been reported. GABA(C) receptors were shown to be functional by studying [Ca²⁺]i levels and hormone release. And functional GABA(C) receptors were also found in pituitary thyroid-stimulating hormone (TSH) cells.

Fig.1 Influences of GABA synthesis and function.

Application of GABRR2 Membrane Protein in Literature

Filatova E., et al. GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells. Frontiers in Pharmacology. 2017, 8: 89. PubMed ID: 28293190

The results confirm the hypothesis that the peptide may affect the interaction of GABA with GABAA receptors.
Hernandez C.C., et al. Deleterious Rare Variants Reveal Risk for Loss of GABA_A Receptor Function in Patients with Genetic Epilepsy and in the General Population. PLoS ONE. 2016, 11 (9): e0162883. PubMed ID: 27622563

The article suggests that GABA(A) receptor function is strongly associated with variants scored as deleterious and mapped within the N-terminal and transmembrane domains.
Förstera B., et al. Potentiation of Gamma Aminobutyric Acid Receptors (GABAAR) by Ethanol: How Are Inhibitory Receptors Affected? Frontiers in Cellular Neuroscience. 2016, 10: 114. PubMed ID: 27199667

The review summarizeds the results of the past researches which focus on acute effects of ethanol on GABAergic transmission.
Fatemi S.H., et al. GABA Receptor Subunit Distribution and FMRP-mGluR5 Signaling Abnormalities in the Cerebellum of Subjects with Schizophrenia, Mood Disorders, and Autism. Schizophrenia research. 2015,167: 1-3,42–56. PubMed ID: 25432637

This article suggests that the GABA signaling system has been hypothesized to contribute to the pathology of major psychiatric disorders including schizophrenia, bipolar disorder, major depression, and autism.
Naffaa M.M., et al. Investigating the Role of Loop C Hydrophilic Residue ‘T244’ in the Binding Site of ρ1 GABAC Receptors via Site Mutation and Partial Agonism. PLoS ONE. 2016,11(5): e0156618. PubMed ID: 27244450

This research is aiming to explore the function of Thr244 in the binding of agonists as an initial step during channel gating by moving loop C towards the ligand.

GABRR2 Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-GABRR2 antibody development services.

Creative Biolabs' skillful scientists are glad to leverage our expertise and advanced technologies to help you with the member protein research. If you are interested, please feel free to contact us for more details.

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