Introduction of GABRR2
The Gamma-aminobutyric acid receptor subunit rho-2(GABRR2), which in humans is encoded by the GABRR2 gene, is also known as a GABA-ρ receptor. GABRR2 is a member of the rho subunit family. GABA receptors are ligand-gated chloride channels, where GABA acts at. GABA is a major inhibitory neurotransmitter in the mammalian brain. GABA(A) receptor subunit rho-2(GABRR2) could play an important role in retinal neurotransmission.
|Basic Information of GABRR2|
|Protein Name||Gamma-aminobutyric acid receptor subunit rho-2|
|Aliases||GABA(A) receptor subunit rho-2, GABA(C) receptor|
|Organism||Homo sapiens (Human)|
Function of GABRR2 Membrane Protein
GABA(C) receptors are bicuculline- and baclofen-insensitive ionotropic GABA receptors which are formed by subunits. GABA(C) receptors may simply be a subset of GABA(A) channels. GABRR2 are located in certain areas of the central nervous system and in the retinas in humans. They form Cl- channels, assumed to organize in either homo- or heteromers of the humans. Outside of the central nervous system and retina, the expression of GABA(C) receptor subunits has been reported. GABA(C) receptors were shown to be functional by studying [Ca2+]i levels and hormone release. And functional GABA(C) receptors were also found in pituitary thyroid-stimulating hormone (TSH) cells.
Fig.1 Influences of GABA synthesis and function.
Application of GABRR2 Membrane Protein in Literature
The results confirm the hypothesis that the peptide may affect the interaction of GABA with GABAA receptors.
The article suggests that GABA(A) receptor function is strongly associated with variants scored as deleterious and mapped within the N-terminal and transmembrane domains.
The review summarizeds the results of the past researches which focus on acute effects of ethanol on GABAergic transmission.
This article suggests that the GABA signaling system has been hypothesized to contribute to the pathology of major psychiatric disorders including schizophrenia, bipolar disorder, major depression, and autism.
This research is aiming to explore the function of Thr244 in the binding of agonists as an initial step during channel gating by moving loop C towards the ligand.
GABRR2 Preparation Options
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